Alignment of subfamily 1B

Alignment of P_1B ATPases (Cu⁺ + Cu²⁺ + Cd²⁺, Zn²⁺, Pb²⁺, and Co²⁺)

The alignment was performed on The Danish Biotechnological Database with the programme CLUSTALW with default settings. The alignment was refined by hand.
The grouping of P-type ATPases and the nomenclature is adopted from the work described in Axelsen, K.B. & Palmgren, M.G. (1998) J. Mol. Evol. 46: 84-101.
The sequence numbers refer to the position of the sequence in a phylogenetic tree of P-type ATPases.
The sequences with sequence numbers in parantheses are not included in the phylogenetic tree, but show more than 90 % sequence identity with the sequence with the specified number.
The positions of the transmembrane helices are predicted with the TMHMM server at The Center for Biological Sequence Analysis and the method of von Heijne. The positions might, therefore, be slightly different in the proteins in vivo.
The segments a-h conserved in all P-type ATPases are the amino acid stretches used for the phylogenetic analysis.
Amino acids in the alignment shown in CAPITALS are present in 70% (49 of 70) of the P_1B ATPases. The putative ancestor protein (Q58378) is not included in this calculation.
Amino acids shown in italics are part of putative metal binding domains. The amino acids in ITALIC CAPITALS are present in 80% of the putative metal binding domains. These amino acids are also indicated at the bottom of the alignment. The PROSITE HMA domain (PS01047) recognises 29-31 amino acids in the N-terminal part of this domain.
Number Accession    Organism                           Name
used   number                                                            1                                                                                                    100 101                                                                                                  200 201                                                                                                  300 301                                                                                                  400 401                                                                                                  500 501                                                                                                  600 601                                                                                                  700 701                                                                                                  800 801                                                                                                  900 901                                                                                                 1000 1001                                                                                                1100 1101                                                                                                1200 1201                                                                                                1300 1301                                                                                                1400 1401                                                                                                1500 1501                                                                                                1600 1601                                                                                                1700 1701                                                                                                1800 1801                                                                                                1900 1901                                                                                                2000        2011
Probable Cd²⁺, Zn²⁺ Pb²⁺, and Co²⁺ transporting ATPases
  23   P94888    Lactococcus lactis                    CadA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .........msekmtektyr IeGlsCtnCagkfEknvkql pGVtsatVnfgaskisVegq ttiee........leeagaf enliirddqendeqvr.... .................... .skesfikrnialiislgfi lvavisqlsl.......... .................... .gedhlltkalyilaiiigg fdlfkegfsdLik.....ld fsMesLmtiaiigAafigew .................... ......aegsivvilfaise alErfsmdkarqsirsLmdi apkeAlirr.nnv....... ................eqlv svdkididDimiikPGqkia mDGlvinGhssvnqaaiTGE svPVeKqlddeVfaGtlNee GilevkvtkkvtdttiakIi hLVeeAQgerapaqafvDkf akyytPfiiimallivvvpp lffgg............... ................dwnk wlyqglsilvvgCPCsLvis tPvsivsaignaAknGvLvK ggvyLEeighlraiaFDKTG TLTkGkpvVtdfia.tss.. .........etdinyls... iisslEslSqHPlasAIlne adktnvdyk..siqiedfqs itGkGltgihqni....... .................... .................... .....ryyiGspklfsasvi ee...tavkvqyrqfqeqgk TamyfgtdeqilGviavaDe vrdssaaviseLhklsieh. ..timlTGDntktAesigkq lGvte..ikgdlmPqeKlds ikaLrt..........tynk VaMVGDGiNDAPALAastvG iAmGgaGtDtAletADvaLm gd......dLqklpfivrLs rqTlkvikqNitfslgikll alllvipgw.......ltlw iAi.vadmgatllVtlNglr Lmkvk............... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  24   Q60048    Listeria monocytogenes                CadA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ............maektvyr VdGlsCtnCaakfErnvkei eGVteaiVnfgaskitVtge asiqq........leqagaf ehlkiipekesftdpehft. .................... .dhqsfirknwrlllsglfi avgyasqimn.......... .................... .gedfyltnalfifaifigg yslfkegfknLlk.....fe ftMetLmtiaiigAafigew .................... ......aegsivvilfavse alErysmdkarqsirsLmdi apkeAlvrr.sgt....... ................drmv hvddiqiGDimiikPGqkia mDGhvvkGysavnqaaiTGE siPVeKniddsVfaGtlNee GllevavtkrvedttiskIi hLVeeAQgerapaqafvDtf akyytPaiiviaaliatvpp llfgg............... ................nwet wvyqglsVlvvgCPCALvvs tPvaivtaignaAknGvLvK ggvyLEeigglkaiaFDKTG TLTkGvpvVtdyie.lte.. .........atniqhnknyi imaalEqlSqHPlasAIiky getremdlt..sinvndfts itGkGirgtvdgn....... .................... .................... .....tyyvgspvlfkella sq.ftdsihrqvsdlqlkgk TamlfgtnqklisivavaDe vrsssqhvikrLhelGiek. ..timlTGDnqatAqaigqq vGvse..iegelmPqdKldy ikqLki..........nfgk VaMVGDGiNDAPALAaAtvG iAmGgaGtDtAietADvaLm gd......dLqklpftvkLs rkTlqiikqNitfslvikli alllvipgw.......ltlw iAi.madmgatllVtlNglr Lmkvkd.............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  25   P30336    Bacillus firmus                       CadA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...msdqkaitseqemkayr VqGftCanCagkfEknvkql sGVedakVnfgaskiaVygn atiee........lekagaf enlkvtpeksarqasqevke dtke................ .dkvpfykkhstllyaslli tfgylssyvn.......... .................... .geenivttllflasmfigg lslfkvglqnLlr.....fe fdMktLmtvaviggaiigew .................... ......aevaivvilfaise alErfsmdrarqsirsLmdi apkeAlvkr.ngq....... ................eimi hvddiavGDimiVkPGqkia mDGvvvsGysavnqtaiTGE svPVeKtvdneVfaGtlNee GlleveitklvedttiskIi hLVeeAQgerapsqafvDkf akyytPiimiiatlvaivpp lffdg............... ................swet wiyqglaVlvvgCPCALvis tPisivsaignaAkkGvLvK ggvyLEemgalkaiaFDKTG TLTkGvpaVtdynv.lnk.. .........qinekells.. iitalEyrSqHPlasAImkk aeeenitys..dvqvedfss itGkGikgivngt....... .................... .................... .....tyyiGspklfkellt nd.fdkdleqnvttlqnqgk TamiigtekeilaviavaDe vresskeilqkLhqlGikk. ..timlTGDnkgtAnaiggq vGvsd..ieAelmPqdKldf ikqLrs..........eygn VaMVGDGvNDAPALAastvG iAmGgaGtDtAletADvaLm gd......dLrklpstvkLs rkTlniikaNitfAiaikfi asllvipgw.......ltlw iAi.lsdmgatllValNglr Lmrvke.............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  26   P37386    Staphylococcus aureus                 CadD              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .....mdsstktltedkqvy rVeGfsCanCagkfEknvke lsGVhdakVnfgaskidVfg satved.lekagafenlkva pekarrrvepvvtedknvyr VeGfsCanCagkfEknvkql aGVqdakVnfgaskidVygn asvee........lekagaf enlkvipeklanpsiqavke dtkapke............. .ekipfykkhstllfatlli afgylshfvn.......... .................... .gednlvtsmlfvssivigg yslfkvgfqnLir.....fd fdMktLmtvavigAaiigew .................... ......aeasivvilfaise alErfsmdrarqsirsLmdi apkeAlvrr.ngq....... ................eimi hvddiavGDimiVkPGekia mDGiiinGvsavnqaaiTGE svPVaKtvddeVfaGtlNee GllevkitkyvedttiskIi hLVeeAQgerapaqafvDkf akyytPiimviaalvavvpp lffgg............... ................swdt wvyqglaVlvvgCPCALvit tPisivsaignaAkkGvLiK ggvyLEelgaikaiaFDKTG TLTkGvpvVtdfkv.lnd.. .........qveekelfs.. iitalEyrSqHPlasAImkk aeqdnitys..dvrvkdfts itGrGiqgnidgt....... .................... .................... .....tyyiGsprlfkelnv sd.fslefenkvkvlqnqgk TamiigtdqtilGviavaDe vretsknvilkLhqlGikq. ..timlTGDnqgtAeaigah vGvsd..iqsellPqdKldy ikkmka..........ehgn VaMiGDGvNDAPALAastvG iAmGgaGtDtAietADiaLm gd......dLsklpfavrLs rkTlniikaNitfAigikii alllvipgw.......ltlw iAi.lsdmgatilValNslr Lmrvkdk............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
 (26)  P20021    Staphylococcus aureus                 CadA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...mseqkvklmeeemnvyr VqGftCanCagkfEknvkki pGVqdakVnfgaskidVygn asvee........lekagaf enlkvspeklanqtiqrvkd dtkahke............. .ektpfykkhstllfatlli afgylshfvn.......... .................... .gednlvtsmlfvgsivigg yslfkvgfqnLir.....fd fdMktLmtvavigAtiigkw .................... ......aeasivvilfaise alErfsmdrsrqsirsLmdi apkeAlvrr.ngq....... ................eiii hvddiavGDimiVkPGekia mDGiivnGlsavnqaaiTGE svPVsKavddeVfaGtlNee GlievkitkyvedttitkIi hLVeeAQgerapaqafvDkf akyytPiimviaalvavvpp lffgg............... ................swdt wvyqglaVlvvgCPCALvis tPisivsaignaAkkGvLvK ggvyLEklgaiktvaFDKTG TLTkGvpvVtdfev.lnd.. .........qveekelfs.. iitalEyrSqHPlasAImkk aeqdnipys..nvqveefts itGrGikgivngt....... .................... .................... .....tyyiGspklfkelnv sd.fslgfennvkilqnqgk TamiigtektilGviavaDe vretsknviqkLhqlGikq. ..timlTGDnqgtAnaigth vGvsd..iqselmPqdKldy ikkmqs..........eydn VaMiGDGvNDAPALAastvG iAmGgaGtDtAietADiaLm gd......dLsklpfavrLs rkTlniikaNitfAigikii alllvipgw.......ltlw iAi.lsdmgatilValNslr Lmrvkdk............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  27   Q59997    Synechocystis PCC6803                 CoaT/slr0797      .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .......mvvtpplssafrf snlfkdhpdavaaiacgglv flgwqmlnlg.......... .................... ...wlgiaffvltaayvigG fdnareglttLfee....ke fdvdlLmivaalgAaglglw rrey................ ...tlivdgavlilifaisg alEgyamqrtersiqgLmsL tadvArvlr.ngq....... ................eqti piselkmGDqvlVkPGelvP tDGlvieGfstlnqasiTGE smPVeKaiGdeVfaGtiNgn Gvlrlkihqppessliqrvi rLVqqAQteappsqqfierf ecgya.kviviaglllgtlp pfllgw.............. ................swee tiyraliflvvasPCALmas impallsgiangArqGiLfK ngaqLErigrvrviaFDKTG TLTtGkpeVvni...lat.. .........qpstdk..llq iaaalEslSeHPigeAIadf trqqnqawa....tarnvqa qaGqGiigdiegq....... .................... .................... .....qaivGkavfvqaqvn h..vatnlieqsqqweaegk TvvwvayageilGliavaDt vrptaaqaiarLkrlGier. ..ivmlTGDnsrtAhsiAqq vGvnq..vyAellPedKvdv irqLqk..........qyqs VaMVGDGiNDAPALAqAsvG iAmGaaGsDvAletADivLm ad......rLerlehairLg rraqgvvkqNivfAlgfvmi llianfagn.......itlp fgv.lghegStviVtlsglr Llrg................ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O31688    Bacillus subtilis                     YkvW              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... mneqvivqrdpheplktdkr eknwaqhaeliaalvsgali lagwllsgyq.......... .................... ...vlsiilfll..afvigG fakakegieetles....kt lnvelLmifaaigsaligyw .................... ......aegailififslsg alEtytmnkssrdltsLmqL epeeAtlmv.nge....... ................tkrv pvsdlqaGDmivikPGerva aDGiiesGstslDeSalTGE smPVeKntGdtVftGtvNrn GsltvrvtkanedslfrkIi kLVesAQnsvspaqafierf enayv.kgvliavalllfvp hfalgw.............. ................swse tfyramvfmvvasPCALvas impaalslisngArnGmLvK gsvfLEqlgsvqmiaFDKTG TvTkGqpaVetir..iae.. .........gfseae..vle avyaiEtqSsHPlaqAItay aesrgvnqs....gyisiee tsGfGvmaevsga....... .................... .................... .....kwkvGkagfigeem. ...aaqfmkqtasdviqsgh TivfvkkddqiaGcialkDq irpeakevmeeLnrlGik.. ..tamlTGDhedtAqaiAke aGmtt..vvAeclPdqKvne ikrLke..........efgt iaMVGDGiNDAPALkaAdvG iAmGg.GtDvAletADmvLm kn......dLkklvnmcrLs rkmnriikqNivfslavicl licanflqa.......melp fgv.ighegStilVilNglr Llk................. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  28   Q59998    Synechocystis PCC6803                 ZiaA/slr0798      .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .......mtqssplktqqmq VgGMdCtsCklkIEgslerl kGVaeasVtvatgrltVtyd pkqvse........itiqer IaalGYtlaepkssvtlngh khphshreeghshshga... .gefnlkqellpvltaialf tiailfeqplhn........ .................... .tpgqiaefaviipayllsG wtvlktagrnilrg....qi fdenfLmtiatlgAlaihql .................... ......peavavmlffrvGe lfqeysvgrsrrsikaLlea rpdtAnlkr.ngt....... ................vqqv spetvqvdDlilVkPGekvP lDGeilgGtsqvDtSalTGE svPgtvkpGdtilaGmiNqs Gvltirvtklfsessiakvl dLVenAsskKastekfitqf aryytPvivflslavallpp lfipga.............. ................drad wvyralvllvisCPCgLvis iPlgyfggiggaAkhGiLiK gstfLdsltavktvvFDKTG TLTkGtfkVtqvvt.kng.. .........fsesellt... laakaEshStHPialsIr.e ayaqsiads....evadyee iaGhGiravvqnq....... .................... .................... .....vviaGndrllh.... ......rekidhdtcdvag. TvvhlavdgrygGyiliaDe ikedavqairdLkrmGvek. ..tvmlTGDseivAqsvAqq iGlda..fvAellPeeKvde ieqLldps........gkak lafVGDGiNDAPviArAdvG iAmGglGsDaAietADvvLm td......apskvaeaihva rkTrqivvqNivlAlgikal fialgtigl.......atlw eAv.fadvgvallailNatr iak................. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   Q9SW66    Arabidopsis thaliana                  HMA1/At4g37270    .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ....mepatltrsssltrfp yrrglstlrlarvnsfsilp pktllrqkplrisaslnlpp rsirlravedhhhdhhhdde qdhhnhhhhhhqhgccsvel kaeskpqkmlfgfakaigwv ranylrehlhlccsaaamfl aaavcpylappep....... .................... .pyikslqnafmivgfplvG vsasldalmdiag.....gk vnihvLmalaafasvfmgna .................... ......legglllamfnlah iaEefftsrsmvdvkeLkes npdsAllievhngnvpn... ...........isdlsyksv pvhsvevGsyvlVgtGeivP vDcevyqGsatitiehlTGE vkPleakaGdrVpgGarNld GrmivkatkawndstlnkIv qLteeAhsnKpklqrwlDef genyskvvvvlslaiaflgp flfkwpfls........... ..............taacrg svyralglmvaasPCALavA .PlayataisscArkGiLlK gaqvLdalaschtiaFDKTG TLTtGgltckaiepiyghqg gtnssvitccipncekeala vaaamEkgttHPigrAvvdh svg.....dlpsifvesfey fpGrGltatvngvktvae.. .................... .................... esrlrkaslGsiefitslfk sedeskqikdavnassygkd fvhaalsvdqkvtlihleDq prpgvsgviaeLkswarlr. ..vmmlTGDhdssAwrvAna vGIte..vycnlkPedKlnh vkniare.........aggg liMVGeGiNDAPALAaAtvG ivlaqrasatAiavADilLl rd......nitgvpfcvaks rqTtslvkqNvalAltsifl aalpsvlgf.......vplw ltv.llheggtllVclNsvr glndpswswkqdivhlinkl rsqeptssssnslssah... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O84732    Chlamydia trachomatis                 ZntA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ......mspqlfsspfsrel lsyffesgmaeenspllsqk nrrlsqnltlksayislaly lgsllshwig.......... .................... ...yqalssllliltfflaG tpaliksfedild.....rt vnidiLmtsaafgsifigga .................... ......legalllvlfaise slgamvsgkakstlasLkhL aptvAwvvqqdgs....... ................lqkv lvqnvkvGeiirVksGevvP lDGkiiqGassinlmhlTGE kiPkscgiGdtipaGahNle GsfdlqvlrigaestiahIi nLVvqAQssKpklqqrlDry sstyaltifaisaciaiggs lfttlpflg........... .................pds afyralafliaasPCALiiA iPiaylsainacAkhGvLlK ggvvLdrlvscnsvvmDKTG TLTtGdltcsgcedfgp... .............esplfys cvlamEqsSsHPiaqAIvny ltek....qvrslpatqctt ipGeGvsgefnge....... .................... .................... .....qafvGrvstalryvp .eeyreqlreraqqaqergd Tc.siaclgkrvslfyfrDv prhdaadivsyLkknGyp.. ..vcmlTGDhrisAentArl lGIde..vfydltPdnKlsk iqeLak...........srq imMiGDGiNDAPALAqAtvG iAmGeaGsatAieaADvvLl nq......gLsslpwlidka kkTrrivsqNlalAlaiilf isgpAsmgv.......iplw lav.ilhegStviVglNalr Llknt............... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O64474    Arabidopsis thaliana                  HMA4/At2g19110    .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..................ma lqnkeeekkkvkklqksyfd VlGicCtsevpiIEnilksl dGVkeysVivpsrtviVvhd sllisp........fqiaka lnearleanvrvngetsfkn .................... .tsfknkwpspfavvsglll llsflkfvys.......... .................... ......plrwlavaavaagi ypilakafasikr.....pr idiniLviitviatlamqdf .................... ......meaaavvflftisd wlEtrasykatsvmqsLmsL apqkAiiaetge........ ..................ev evdevkvdtvvaVkaGetiP iDGivvdGncevDektlTGE afPVpKqrdstVwaGtiNln Gyicvkttslagdcvvakma kLVeeAQssKtksqrliDkc sqyytPaiilvsacvaivpv imkvhn.............. .................lkh wfhlalvVlvsgCPCgLiLs tPvatfcaltkaAtsGlLiK sadyLdtlskikivaFDKTG TiTrGefiVidfkslsr... ...........dinlrslly wvssvEskSsHPmaatIvdy aksvsve..prpeevedyqn fpGeGiygkidgn....... .................... .................... .....difiGnkkiasrag. .....cstvpeievdtkggk TvgyvyvgerlaGffnlsDa crsgvsqamaeLkslGik.. ..tamlTGDnqaaAmhaqeq lGnvldvvhgdllPedKsri iqefkk...........egp taMVGDGvNDAPALAtAdiG ismGisGsalAtqtgniiLm sn......dirripqavkLa rrarrkvveNvclsiilkag ilalAfagh........pli wAavlvdvgtcllVifNsml Llrekkkignkkcyrastsk lngrklegdddyvvdleagl ltksgngqckssccgdkknq envvmmkpssktssdhshpg ccgdkkeekvkplvkdgccs ektrksegdmvslssckkss hvkhdlkmkggsgccaskne kgkevvaksccekpkqqves vgdcksghcekkkqaedivv pvqiighalthveielqtke tcktsccdskekvketglll ssentpylekgvlikdegnc ksgsenmgtvkqschekgcs dekqtgeitlaseeetddqd cssgccvnegtvkqsfdekk hsvlvekegldmetgfccda klvccgntegevkeqcrlei kkeehcksgccgeeiqtgei tlvseeetestncstgccvd keevtqtchekpaslvvsgl evkkdehcesshravkvetc ckvkipeacaskcrdrakrh sgksccrsyakelcshrhhh hhhhhhhhvsa 
   -   O26511    Methanobacterium thermoautotrophicum  MTH411            .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .mgceCssCspsgngne... .................... .................... .................... .................... ........eilvmaasaall aagilldlqg.......... .................... ....smisvplliaavvaaG yrifpaavrsvlr.....gh ftvhvLiliavigAialgdy .................... ......teaalvtvlyhiae ylEeyahrrshrsvesLikL rprtArvld.gg........ ................erim gvedveeGstigikPGetvP lDGtvksGtsqvDqSsiTGE slPVtvgeGdqVfaGtqNld Gylevkvtrtseatvlagvi etVrrsalrrsrrerfierf asiytPtvtglaaltalipv ltgg................ ................dplt wiyralvllvisCPCALlis tPvamvsgmtaaAgrGiLiK gsefLEkmastgciiFDKTG TLTeGrpeViavepee.... .............rrdeilr iaaslErkSgHPiaeAIvns ysg.......rtvdvtdfrs ipGrGvsgyieg........ .................... .................... ....vrytlGspetgggn.. ...............pdrg. TevqltgpegviGvirlrDs irksagritgrLrerGig.. ..tlmlTGDtedsAaavAae iGaer..yrggllPedKmri ireLss...........rki tvMVGDGvNDAPALAaAdvG iAmGvrGsDvAietADitLv ed......dLeridelidis rrTmdiirvNtgltvavkls lavlsvagl.......vplw vAvavgdmglslfVitNsll Larf................ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O32219    Bacillus subtilis                     YvgW              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........mrlvkqeyv ldGldCsnCarkIEngvkgi kGIngcaVnfaastltVsad gkeeqw........vtnkve kkvksidphvtvrqkhikks addgyrn............. ....rmvnmlirmaaavilg aaaylvqs............ .................... ....gtiefflflgayliiG gdiiiravkniirg....qv fdehfLmalatigAfliqqy .................... ......pegvavmlfyqiGe lfqgaavsrsrksisaLmdi rpdyAnlkt.kng....... ................ieqv ssedvqtGDiivVnPGesiP lDGkvvqGsamvDtSalTGE svPrkaaeGqdVmsGfiNqn GvlhievtkgyqesavskIl dLVqnAssrKartenfitkf akyytPavviiavllafvpp lvlsga.............. ................alsd wvyraliflvisCPCALvvs iPlgffggigaaskaGvLvK gsnyLEalnqvkyavFDKTG TLTkGsfeVteikp.aeg.. .........ftkdrlle... aaayaElhSqHPiaesvr.k aygkmlssd....eiesyee isGhGifakvngt....... .................... .................... .....eilaGnkklme.... ......reqiedvpdenag. TivhvavdqryaGaiiiaDe ikedaaqavadLkslGikq. ..tamlTGDskqtgeavgkq lGIge..vyAellPqdKvaq veaLeakll.......psek lifVGDGiNDtPvLArAdiG vAmGglGsDaAveaADivLm td......qpskiaeairia krTrrivwqNigfAlgvkai flilgafgi.......atmw eAv.fsdvgvtllavaNamr vmrlknk............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  29   Q59465    Helicobacter pylori strain 26695      CadA/HP0791       .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...............mqeyh IhnldCpdCasklErdlnel dyVkkaqInfstsklfldts dfekvk........afikqn ephlslsfkeatekp..... .................... .....lsftpliitimvflg aililhlnp........... .................... spliekamffvlalvylvsG kdvilgafrgLrkg....qf fdenaLmliatiaAffvgay .................... ......eesvsimvfysaGe flqklavsrskkslkaLvdv apnlAylkk.gde....... ................lvsv apedlrvnDivvVkvGekvP vDGvvvkGesllDeralsGE smPVnvsenskVlgGslNlk avleiqvekmykdssiakvv dLVqqAtneKsetekfitkf sryytPsvlfialmiavlpp lfsmg............... ................sfde wiyrglvalmvsCPCALvis vPlgyfggvgaasrkGiLmK gvhvLEvltqaksiaFDKTG TLTkGvfkVtdivp.qng.. .........hskeevlh... yascsqllStHPialsIq.k aceemlkddkhqhdiknyee vsGmGvkaqchtd....... .................... .................... .....liiaGnekmld.... ......qfhiahspskeng. TivhvafnqtyvGyivisDe ikddaieclrdLkvqGien. ..fcilsGDrksatesiAqt lGce...yhAsllPeeKtsv fktfker.........ykap aifVGDGiNDAPtLAsAdvG igmG.kGselskqsADivit nd......sLnslvkvlaia kkTksiiwqNilfAlgikav fivlglmgv.......aslw eAv.fgdvgvtllalaNsmr amra................ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  30   Q10866    Mycobacterium tuberculosis            CtpG/Rv1992c      .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...................m ttvvdaevqltvvsdaagrm rvqatgfqfdagravaiedt vgkvagvhavhayprtasiv iwysraicdtaailsaiida etvpaaaVpayasrsasnrk agvvqki.......idwstr tlsgvrrdvaaqpsetsdac cdge..dnedrepeq..... .qlwqvaklrraafsgvllt aslvaawayp.......... .................... ...lwpvvlglkalalavga stfvpsslkrLaeg.....r vgvgtLmtiaalgAvalgel g................... .......eaatlaflfsise glEeyatartrrglraLlsL vpdqAtvlregt........ ................etiv astelhvGDqmiVkPGerla tDGiiraGrtalDvSaiTGE svPVevgpGdeVfaGsiNgl GvlqvgvtataannslarIv hiVeaeQvrKgasqrlaDci arplvPsimiaaaliagtgs vlgn................ .................plv wieralvVlvaaaPCALaiA vPvtvvasigaasrlGvLiK ggaaLEtlgtiravalDKTG TLTanrpvVidvattng... ............atreevla vaaalEarSeHPlavAvlaa tqat........taasdvqa vpGaGligrldgr....... .................... .................... .....vvrlGrpgwldaa.. ......eladhvacmqqaga TavlverdqqllGaiavrDe lrpeaaevvagLrtgGyq.. ..vtmlTGDnhatAaalAaq aGIeq..vhAelrPedKahl vaqLra...........rqp taMVGDGvNDAPALAaAdlG iAmGamGtDvAietADvaLm gq......dLrhlpqaldha rrsrqimvqNvglslsiitv lmPlAlfgi.......lgl. aAvvlvhefteviViaNgvr agrikplagppktpdrtipg .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O33448    Proteus mirabilis                     PpaA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...MdCptCaqkIEtavlkv vGVkqakIlfateklvVdad ..ir..........tdvisa VksaGFelfdissags.... ..................qp pakqsllkessfviilailm aiswgaefid.......... .................... ....pqagraafiattligl fpivkkllrlirsg....tp faietLmsvaaigAlfinat .................... ......eeaamvillfmiGe mlEsyaagrarrgvsaLmaL vpeeAvvik.egk....... ................kqtv pvaqlrpGDiieiaPGralP tDaelitafasfDeSalTGE svPVerlqGekVaaGclsvd rsvqmkvvseqgqnaidrIl qLieeAeerKapierfvDrf sryytPlimlfsalviiipp llfaq............... ................pwet wfyrgltllligCPCALvis tPaaitsalaaatkrGaLiK ggaaLEqlgtvntvalDKTG TLTeGkpqVtdvia.nvg.. .........fnekellm... lassvEvgShHPlakAIink aqeqqidvv....eadnrka laGkGiegylnnq....... .................... .................... .....hilvsaptqlsetip lsa...qwqqqvarledegk TvvvvlkedqfiGviamqDt lrndaiesmkekkvlksmni n.avmlTGDnpraAaaiAqk lGmd...frAgllPedKvts vmeisq...........thn tmMVGDGiNDAPAmkaAtiG vAmG.sGtDvAletADaaLt hn......rLtglpeiiqLs raTrkiireNitiAlglkai flvtslfgi.......tglw vAv.ladsgatalVtaNavr Llkvklksphqd........ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  31   P37617    Escherichia coli                      ZntA/o732         .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .......mstpdnhgkkapq faafkplttvqnandcccdg acsstptlsenvsgtryswk VsGMdCaaCarkVEnavrql aGVnqvqVlfateklvVdad ndir..........aqvesa lqkaGYslrdeqaaeep... .................... ..qasrlkenlplitlivmm aiswgleqfn.......... .................... ....hpfgqlafiattlvgl ypiarqalrliksg....sy faietLmsvaaigAlfigat .................... ......aeaamvlllfliGe rlEgwaasrarqgvsaLmaL kpetAtrlr.kge....... ................reev ainslrpGDvieVaaGgrlP aDGkllspfasfDeSalTGE siPVeratGdkVpaGatsvd rlvtlevlsepgasaidrIl kLieeAeerrapierfiDrf sriytPaimavallvtlvpp llfaa............... ................swqe wiykgltllligCPCALvis tPaaitsglaaaArrGaLiK ggaaLEqlgrvtqvaFDKTG TLTvGkprVtaihp.atg.. .........isesellt... laaavEqgatHPlaqAIvre aqvaelaip....taesqra lvGsGieaqvnge....... .................... .................... .....rvlicaagkh..... ...padaftglinelesagq TvvlvvrnddvlGvialqDt lradaataiseLnalGvk.. ..gvilTGDnpraAaaiAge lGle...fkAgllPedKvka vteLnq...........hap laMVGDGiNDAPAmkaAaiG iAmG.sGtDvAletADaaLt hn......hLrglvqmieLa raThanirqNitiAlglkgi flvttllgm.......tglw lAv.ladtgatvlVtaNalr Llrrr............... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O68082    Rhodobacter capsulatus                                  .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..................mt edtsrlvltwatiaamvlaa aghwifpglgg......... .................... ...ggwvetlallsvfltgG vpaayravgaLiee....rq ldidlLmvvaalaAaavgaa .................... ......legavlltlfslst tlEhramgrarraieaLmeL rpdrAlkrqggd........ ................tvev avetlvpGDvvilrPGarvP vDGvivaGegaiDeStiTGE svPVhKapGaqVfeatvNlh Gvleievrrelgestvarmi aLVteAQaarspserfsawf gqrytvavllaavsafaafw aighg............... .................wna alykaatllvaasPCAivis vPaailsalsvaArgGvLfK ggaaLEtlakvetfaFDKTG TLTtGkqeivdihceg.... .............dealfla rlagiEaqSeHPiatAIrqh vaarg....ivplpvreara vpGeGmvavddeg....... .................... .................... .....viwaGnarlaqrmg. ..araaetlalpavlenapr TlvllgrgakilGgvtceDr prdstpaglaaLragGvgq. ..iamlTGDrravAerigae lGIgadeihAdlrPedKvki vadLta..........rg.r VafVGDGvNDAaALArAdvG iAmGvaGsevAlqaADvaLl ad......disrlseahrLa grTariirqNlvfAmgamav lvlsglffe.......lplp vav.igheggtvlVvlNglr Lladpirkarg......... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O69710    Mycobacterium tuberculosis            Rv3743c           .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..................ma vrelsparctsasplvlarr tklfalsemrwaalalglfs aglltqlcga.......... .................... ...pqwvrwalflacyatgG gwepglaglqaLqr.....r ldvdlLmvvaaigAaaigqi .................... ......aegallivifatsg alEalvtartadsvrgLmgL apgtAtrvgaggg....... ................eetv naadlriGDivlVrPGeris aDatvlaGgsevDqatvTGE plPVdKsiGdqVfaGtvNgt GalrirvdrlardsvvarIa tLVeqAsqtKartqlfiekv eqrys.igmvavtlavfavp .plwge.............. ................tlqr allramtfmivasPCAvvLA tmppllaaianagrhGvLaK saivmEqlgtttriaFDKTG TLTrGtpelagiw..vye.. .........rrftdd.ellr laaaaEypSeHPlgaAIvka aqsrrirlp....tvgefta hpGcrvtarvdgh....... .................... .................... .....viavGsatallgtag aaaleasmitavdflqgegy TvvvvvcdshpvGllaitDq lrpeaaaaisaatkltGak. ..pvllTGDnratAdrlgvq vGIdd..vrAgllPddKvaa vrqLqa..........ggar ltvVGDGiNDAPALAaAhvG iAmGsarseltlqtADavvv rd......dLttiptviams rrarrivvaNlivAvtfiag lvvwdlaft.......lplp lgv.arhegStiiVglNglr Llrhtawrraagtahr.... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O53160    Mycobacterium tuberculosis            CtpD/Rv1469       .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........mtltacevt aaeapfdrvsktiphplswg aalwsvvsvrwatvalllfl aglvaqlnga.......... .................... ...peamwwtlylacylagG wgsawagaqaLrn.....ka ldvdlLmiaaavgAvaigqi .................... ......fdgallivifatsg alddiatrhtaesvkgLldL apdqAvvvqgdgs....... ................ervv aaselvvGDrvvVrPGdriP aDGavlsGasdvDqrsiTGE smPVaKarGdeVfaGtvNgs GvlhlvvtrdpsqtvvarIv eLVadAsatKaktqlfieki eqrys.lgmvaatlalivip .lmfga.............. ................dlrp vllramtfmivasPCAvvLA tmppllsaianagrhGvLvK savvvErladtsivalDKTG TLTrGiprlasva..pld.. .........pnvvdarrllq laaaaEqsSeHPlgrAIvae arrrgiaip....pakdfra vpGcGvhalvgnd....... .................... .................... .....fveiaspqsyrgap. ........laelapllsaga TaaivlldgvaiGvlgltDq lrpdavesvaamaaltaap. ..pvllTGDngraAwrvArn aGItd..vrAallPeqKvev vrnLqa..........gghq VllVGDGvNDAPAmAaAraa vAmG.aGaDltlqtADgvti rd......eLhtiptiigLa rqarrvvtvNlaiAatfiav lvlwdlfgq.......lplp lgv.vghegStvlValNgmr Lltnrswraaasaar..... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
  32   P96875    Mycobacterium tuberculosis            CtpC/MtaA/Rv3270  .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...mtlevvsdaagrmrvkv dwvrcdsrravavEeavakq ngvrvvhayprtgsvvvwys prrad........raavlaa ikgaahvaaelipar..... ..............aphsae irntdvlrmviggvalallg vrryvfarpp.......... .................... ..llgttgrtvatgvtiftG ypflrgalrsLrs.....gk agtdaLvsaatvaslilren .................... ......vvaltvlwllniGe ylqdltlrrtrraiseLlrg nqdtAwvrltdpsag..... ...........sdaateiqv pidtvqiGDevvVhehvaiP vDGevvdGeaivnqSaiTGE nlPVsvvvGtrVhaGsvvvr GrvvvrahavgnqttigrIi srVeeAQldrapiqtvgenf srrfvPtsfivsaiallitg .................... .................... dvrramtmLliaCPCAvgLs tPtaisaaigngArrGiLiK ggshLEqagrvdaivFDKTG TLTvGrpvVtnivamhkdw. ........ ....epeqvla yaassEihSrHPlaeAvirs teerr....isippheecev lvGlGmrtwadgr....... .................... .................... .....tlllGspsllraekv r..vskkasewvdklrrqae TplllavdgtlvGlislrDe vrpeaaqvltkLranGirr. ..ivmlTGDhpeiAqvvAde lGIde..wrAevmPedKlaa vreLqd..........dgyv VgMVGDGiNDAPALAaAdiG iAmGlaGtDvAvetADvaLa nd......dLhrlldvgdLg eravdvirqNygmsiavNaa glligagga.......lsPv lAa.ilhnaSsvaVvaNssr Liryrldr............ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
Probable Cu⁺, Ag⁺, and Cu²⁺ transporting ATPases
  33   P77871    Helicobacter pylori                   CopA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............mkesfy IeGMtCtaCssgIErslgrk sfVkkieVnllnksanIefn enetn........ldeifkl IeklGYspkktlaeek.... ................keff spnvklalaviftlfvvyls mgamlspsllpksl...... ..............laidnh snflnaclqligtlivmhwG rdfyiqgfkaLwh.....rq pnMssLiaigtsaAlisslw qlylvytdhytd.....qws yghyyfesvcvilmfvmvGk riEnvskdkaldamqaLmkn apktAlkiq.ndq....... ................qiev lvdsivvGDilkVlPGtlia vDGeiieGegelDeSmlsGE alPVyKkvGdkVfsGtfNsh tsflmkatqnnknstlsqIv emihnAQssKaeisrlaDkv ssvfvPsviaiailafvvwl iiapkp.............. ............dfwwnfgi alevfvsVLvisCPCALgLA tPmsilvanqkasslGlffK daksLEkarlvntivFDKTG TLTnGkpvVksvhs...... ...........kiellells lansiEksSeHviakgIvey akeh...n.aplkemsevkv ktGfGisaktdyqgt..... .................... .................... ...keiikvGnseffnpi.. .....ntle.iqengilvlv grainekedellGafvleDl pkkgvkehvaqiknlGin.. ..tfllsGDnrenvkkcAle lGIdg..yisnakPqdKlnk ikeLke..........kgri VmMVGDGlNDAPsLAmsdva vvma.kGsDvsvqaADivsf nn......diksvysaikLs qaTiknikeNlfwAfcYNsv fiPlAcgvlyka.nimlsPa iAg.lamslSsvsVvlNsqr Lr..nfkikdh......... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
 (33)  P55989    Helicobacter pylori strain 26695      HP1072            .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............mkesfy IeGMtCtaCssgIErslgrk sfVkkieVsllnksanIefd enqtn........ldeifkl IeklGYspkkaltkek.... ................keff spnvklalaviftlfvvyls mgamlspsllpesl...... ..............laidnh snflnaclqligalivmhlG rdfyiqgfkaLwh.....rq pnMssLiaigtsaAlisslw qlylvytnhytd.....qws yghyyfesvcvilmfvmvGk riEnvskdkaldamqaLmkn apktAlkmq.nnq....... ................qiev lvdsivvGDilkVlPGsaia vDGeiieGegelDeSmlsGE alPVyKkvGdkVfsGtfNsh tsflmkatqnnknstlsqIi emiynAQssKaeisrlaDkv ssvfvPsviaisilafvvwl iiapkp.............. ............dfwwnfgi alevfvsVLvisCPCALgLA tPmsilvanqkasslGlffK daksLEkarlvntivFDKTG TLTnGkpvVksvhs...... ...........kiellells lalsiEksSeHviakgIvey akeh...n.aplkemsgvkv ktGfGisaktdyqgt..... .................... .................... ...keiikvGnseffnpi.. .....ntle.ikengilvfv graisekedellGafvleDl pkkgvkehiaqiknlGin.. ..tfllsGDnrenvqkcAfe lGIdg..yisnakPqdKlnk ikeLke..........kgqi VmMVGDGlNDAPsLAmsdva vvma.kGsDvsvqaADivsf nn......diksvysaikLs qaTiknikeNlfwAfcYNsv fiPlAcgvlyka.nlmlsPa iAg.lamslSsvsVvlNsqr Lr..nfkikdh......... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
 (33)  O08462    Helicobacter pylori                   CopA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............mkesfy IeGMtCtaCssgIErslgrk sfVkkieVsllnksanIefn enetn........ldeifkl IeklGYspkktlaeek.... ................keff spnvklalaviftlfvvyls mgamlspsllpesl...... ..............lainnh snflnaclqligalivmhlG rdfyiqgfkaLwh.....rq pnMssLiaigtsaAlisslw qlylvytnhytd.....qws yghyyfesvcvilmfvmvGk riEnvskdkaldamqaLmkn apktAlkmq.nnq....... ................qiev lvdsivvGDilkVlPGsaia vDGeiieGegelDeSmlsGE alPVyKkvGdkVfsGtlNsh tsflmkatqnnknstlsqIi emihnAQssKaeisrlaDkv ssvfvPsviaiailafvvwl iiapkp.............. ............dfwwnfgi alevfvsVLvisCPCALgLA tPmsilvanqkasslGlffK daksLEkarlvntivFDKTG TLTnGkpvVksvhs...... ...........kiellells lagsiEksSeHviakgIvey aker...n.aplkemsevkv ktGfGisaktdyqgi..... .................... .................... ...keiikvGnseffnpi.. .....ntle.ikengilvfv graisekedellGvfvleDl pkkgvkehiaqiknlGin.. ..tfllsGDnrenvkkcAle lGIdg..yisnakPqdKlnk ikeLke..........qgqi VmMVGDGlNDAPsLAmndva vvma.kGsDvsvqaADivsf nn......diksvysaikLs qaTiknikeNlfwAfcYNsv fiPlAcgvlyka.nimlsPa iAg.lamslSsvsVvlNsqr Lr..nfkikdh......... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
 (33)  Q59467    Helicobacter pylori                   CopA2             .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............mkesfy IeGMtCtaCssgIErslgrk sfVkkieVsllnksanIefn enetn........ldeifkl IeklGYspkktlaeek.... ................keff spnvklalaviftlfvvyls mgamlspsllpesl...... ..............ltinnh snflnaclqligtlivmhlG rdfyiqgfkaLwh.....rq pnMssLiaigtsaAlisslw qlyfvyts.........qws yghyyfesvcvilmfvmvGk riEnvskdkaldamqaLmkn apktAlkmh.nnq....... ................qiev lvdsivvGDilkVlPGsaia vDGeiieGegelDeSmlsGE alPVyKkvGdkVfsGtfNsh tsflmkatqdnknstlsqIv emihnAQssKaeisrlaDkv ssvfvPsviaiailafvvwl iiapkp.............. ............dfwwnfgi alevfvsVLvisCPCALgLA tPmsilvanqkasslGlffK daksLEkarlvntivFDKTG TLTnGkpvVksvhs...... ...........niellells lagsiEksSeHviakgIvey akeh...n.aplkemsevkv ktGfGisaktdyqga..... .................... .................... ...kevikvGnseffnpi.. .....nale.iqengilvfv grvisekedellGafvleDl pkkgvkehiaqikklGin.. ..tfllsGDnrenvkkcAle lGIdg..yisnakPqdKlnk ikeLke..........kgqi VmMVGDGlNDAPsLAmsdva vvma.kGsDvsvqaADivsf nn......diksvysaikLs qaTiknikeNlfwAfcYNsv fiPlAcgvlyka.nimlsPa iAg.lamslSsvsVvlNsqr Lr..nfkikdh......... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
   -   O32619    Helicobacter felis                    CopA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .............mtkaqfy IeGMtCsaCssgIEralgrk kfVqevgVdliskkafVvyd enqas........ledvfkq IeklGYqprvatdtpntfln ................psfl tpnvklalvllgtlgvlals mfapllp............. ..............lpsflk npfingivqlvlslmvmhmG rnfyvhgfkaLwa.....rq pnMdsLialgtsaAllyslv llfrayt..........hap iegyyfesvcvillfvmaGk rvEenskdkaleamqsLmrh qslnAlkie.ngq....... ................svev pleslqkGDilqilPGsyiP vDGvlfkGeaevDeSmlsGE slPVyKkeGmdlfaGtlNtt ttfqmrathtkaqstlakIl tLiakAQgsKapiarlaDkv agvfvPivigiasiaflvwl vlg................. ................dftr alevfiaiLvisCPCALgLA tPmallvaqkeasllGlffK davsLEkaknvnhviFDKTG TLTlGtplVqevrvae.... ...........gvdrlellt lcaslEaqSeHviakgIvah akeq...g.ialqevqevqa kpGfGikgvvgdq....... .................... .................... .....iikaGnleffnlp.. .....npfg.tleg.iqv.. ...fvgtetqilGvvvlaDs lkegskeaiseLkalGvk.. ..ttllsGDnlenvralAtq lGIqd..yhAqakPedKlkv iqeLka..........qgkv VmMVGDGvNDAPsLAlsdvG vvma.kGsDaslevADvvsf nn......diqsvvsamkLs alTianikqNlfwAfcYNsi aiPlAcgvaykl.gimfnPm lAs.lamslSsvsVvlNaqr Lrgahfkirgshenrhss.. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
  34   P77868    Haemophilus influenzae                HI290             .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ......mldltpqskkisiq IgGMtCqsCanrIEkvlnkk pfVqqagVnfaaeeaqVvfd atqas........eaqiiei IhktGFsahikqan...... ............elpieent sipwrlivlwiinipfligm lgmiggshnlmlp....... .................... ....piwqfalasivqlwla ipfyrgaigsirg.....gl tnMdvLvstgtltiylysaf mlfyhanh...........a mghvyfeasvmvigfvslGk flEdrtkkhslnslsmLlqL tpkkvtvlrnek........ ................wiei aldqvniGeiiranqGeria aDGviesGngwcDeShlTGE srPeeKqkGgkVlaGamvte Gsiiyranqlgsqtllgdmm nalsdAQgsKapiarfaDkv tsvfvPvvlvislvtfalty iltn................ ................dsvs slihavsVLviaCPCALgLA tPaaimvglgkavnaGvwfK daaamEetahvdtvvlDKTG TLTkGeleisalwqpqs... ..........avyseddlyr faaavErqanHPiakAIvqa aex....kmleiptalfskm evGqGiqaeleqvg...... .................... .................... .....tikvGkpdycg.... ......lilpknlediwqia sivavsindepiGafaltDt lkndslhaiqrLqqqnid.. ..vvimsGDqqsvvdyiAkq lGIkk..afgkltPrdKaeq iqkLkd..........lghi VaMVGDGiNDAPALAsAnvs fAmk.sssDiAeqtAsatLm qh......svnqlvdalfia raTlknikqNlffAliYNil giPlAafgf.......lsPi iAg.aamalSsisVlmNalr Lkkvrf.............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
   -   Q9SZC9    Arabidopsis thaliana                  PAA1/At4g35520    .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .......mestlsafstvka tamarssggpslplltiska lnrhftgarhlhplllarcs psvrrlggfhgsrftssnsa lrslgaavlpvirhrlecls ssspsfrsissgggsgfggy nggsgggggggsesgdsksk lganasdgvsvpssdiiild VgGMtCggCsasVkkilesq pqVasasVnlttetaiVwpv peaksvpdwqkslgetlanh slncGFqstprdlvtenffk vfetqpkdk......qarlk esgrelavswapcavclvgh lthflgvnap.......... .................wih aihstgfhvslclitllgpG rklvldgisLlk......gs pnMntLvglgalssfsvssl aamipkl............. gwktffeepvmliafvllGr nlEqrakikatsdmtgLlsv laskArllldgdlqn..... ...............stvev pcnslsvGDlvvilPGdrvP aDGvvksGrstiDeSsfTGE plPVtKesGsqVaaGsiNln GtltvevhrsggetavgdIi rLVeeAQsreapvqqlvDkv agrftygvmalsaatftfwn lfgahvlpsalhng...... ...............spmsl alqlscsVLvvaCPCALgLA tPtamlvgtslgArrGlLlr ggdiLEkfslvdtvvFDKTG TLTkGhpvVteviipenpr. ......hnlndtwsevevlm laaavEsnttHPvgkAIvka ararn..cqtmkaedgtfte epGsGavaivnnk....... .................... .................... .....rvtvGtlewvkrhg. ...atgnsllaleeheinnq svvyigvdntlaavirfeDk vredaaqvvenLtrqGid.. ..vymlsGDkrnaAnyvAsv vGInherviAgvkPaeKknf ineLqk..........nkki VaMVGDGiNDAaALAssnvG vAmGg.GagaAsevspvvLm gn......rLtqlldameLs rqTmktvkqNlwwAfgYNiv giPiAagvllpltgtmltPs mAg.almgvtslgVmtNsll Lryrffsnrndknvkpepke gtkqphentrwkqss..... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
  35   Q59385    Escherichia coli                      YbaR/f834         .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ....msqtidltldGlsCgh CvkrVkesleqrpdVeqadV siteahvtgtasaeqli... ..etIkqaGYdasvsh.... .................... .................... .................... .................... .................... ...pkakplaessipsealt avsealpaataddddsqqll lsGMsCasCvtrVqnalqsv pGVtqarVnlaertalVmgs asp...........qdlvqa VekaGYgaeaieddakrrer qqe..........tavatmk rfrwqaivalavgipvmvwg migdnmmvtadn........ .................... .rslwlviglitlavmvfaG ghfyrsawksLln.....ga atMdtLvalgtgvAwlysms vnlwpqwfp.........me arhlyyeasamiiglinlGh mlEararqrsskalekLldL tpptArlvtdeg........ ................eksv plaevqpGmllrlttGdrvP vDGeitqGeawlDeamlTGE piPqqKgeGdsVhaGtvvqd GsvlfrasavgshttlsrIi rmVrqAQssKpeigqlaDki savfvPvvvvialvsaaiwy ffgpap.............. ................qivy tlviattVLiiaCPCALgLA tPmsiisgvgraAefGvLvr dadaLqrastldtvvFDKTG TLTeGkpqVvavktfadv.. .............deaqalr laaalEqgSsHPlarAIldk ag......dmqlpqvngfrt lrGlGvsgeaegh....... .................... .................... .....alllGnqallneqq. ..vgtkaieaeitaqasqga TpvllavdgkavallavrDp lrsdsvaalqrLhkaGyr.. ..lvmlTGDnpttAnaiAke aGIde..viAgvlPdgKaea ikhLqs..........egrq VaMVGDGiNDAPALAqAdvG iAmGg.GsDvAietAaitLm rh......sLmgvadalais raTlhnmkqNllgAfiYNsi giPvAagilwpftgtllnPv vAg.aamalSsitVvsNanr Llrfkpke............ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
  36   P32113    Enterococcus hirae                    CopA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .........matntkmetfv ItGMtCanCsarIEkelneq pGVmsatVnlatekasVkyt dttt..........erliks VeniGYgailydeahk.... ........qkiaeekqtylr kmkfdlifsailtlplmlam iammlgshgp.......... .................ivs ffhlslvqllfalpvqfyvG wrfykgayhaLkt.....ka pnMdvLvaigtsaAfalsiy ngffpsh............. shdlyfesssmiitlillGk ylEhtaksktgdaikqmmsL qtktAqvlrdgk........ ................eeti aidevmidDilvirPGeqvP tDGriiaGtsalDeSmlTGE svPVeKkekdmVfgGtiNtn GliqiqvsqigkdtvlaqIi qmVedAQgsKapiqqiaDki sgifvPivlflalvtllvtg wlt................. ...............kdwql allhsvsVLviaCPCALgLA tPtaimvgtgvgAhnGiLiK ggeaLEgaahlnsiilDKTG TiTqGrpeVtdvigp..... ...............keiis lfyslEhaSeHPlgkAIvay ga....kvgaktqpitdfva hpGaGisgtin......... .................... .................... ...gvhyfaGtrkrlaem.. .nlsfdefqeqaleleqagk TvmflaneeqvlGmiavaDq ikedakqaieqLqqkGvd.. ..vfmvTGDnqraAqaigkq vGIdsdhifAevlPeeKany vekLqk..........agkk VgMVGDGiNDAPALrlAdvG iAmG.sGtDiAmetADvtLm ns......hLtsinqmisLs aaTlkkikqNlfwAfiYNti giPfAafgf.......lnPi iAg.gamafSsisVllNsls Lnrktik............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
  37   P37385    Synechococcus PCC7942                 SynA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .mpaaivhsadpsstsilve VeGMkCagCvaaVErrlqqt aGVeavsVnlitrlakVdyd aalied.......ptvltte ItglGFraqlrqddnpltlp ............iaeipplq qqrlqlaiaafllivsswgh lghwldhplpg......... .................... .tdqlwfhallatwallgpG rsilqagwqgLrc.....ga pnMnsLvllgtgsAylaslv allwpql............. gwvcffdepvmllgfillGr tlEeqarfrsqaalqnLlaL qpettqlltapssiapqdll .............eapaqiw pvaqlraGDyvqVlPGdriP vDGcivaGqstlDtamlTGE plPqpcqvGdrVcaGtlNls hrlviraeqtgsqtrlaaIv rcVaeAQqrKapvqrfaDai agrfvygvcaiaaltfgfwa tlgsrwwpqvlqqplpglli haphhgmemahphshsplll altlaisVLvvaCPCALgLA tPtailvatglaAeqGiLvr ggdvLEqlarikhfvFDKTG TLTqGqfelieiqpladv.. .............dpdrllq waaalEadSrHPlatAlqta aqa....anlapiaasdrqq vpGlGvsgtcdgr....... .................... .................... .....slrlGnptwvqva.. .........taklptgsaaa TsiwladdqqllacfwlqDq prpeaaevvqaLrsrGat.. ..vqilsGDrqttAvalAqq lGlesetvvAevlPedKaaa iaaLqs..........qgda VaMiGDGiNDAPALAtAavG isla.aGsDiAqdsAgllLs rd......rLdsvlvawnLs qmglrtirqNltwAlgYNvv mlPlAagaflpayglaltPa iAg.acmavSslaVvsNsll Lrywfrrslnhsvsv..... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
   -   O83999    Treponema pallidum                    TP1036            .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............mqvsfv VhGisCtaCvrrIEeavrhv tGaydvyVnpttshlyVhtd lhptehtlf....aqtiida VshaGFkatlldthsttapl aa.........tqpvhpdfv tlkrrvrtslcllvplmyls mghmvhlpipgflhp..... ..................lk yalsfalvqafltlpvlyan rslfragliaLygailrrnt atMdsLislgslssftyglf atariamgvhandtalvshy vadlyfesaamivtlvtvGk ylsalskgrtsraltqLldi kpktArvirqvsvprgasps spttasaasahetheieiei paqdvlvGDtvlVkaGelvP vDGiitsGqatlDeSnvTGE siPVeKgrGdsVisaslvst GflkfraervgehttlaqIi sLVektaasKvpvtklvDav sayfvPsivalsllsgcawl cagas............... .................aef afsiavtVLvisCPCvLgLA vPtalmvatgkgAqmGiLiK saqvfqqmartkviaFDKTG TLTlGrptlshihtlhptyn ..............eedilh layslEvcSgHPlaaAIsva aqrkg....mtplaitdfns eqGlGlrarlvhts...... .................... .................... ..yaktvmvGnarmmvahs. ....idgmdtylspshnlee TplfvaadknlvGvlfvsDp vkvhssaaigaLhkrGiq.. ..tlmlTGDvkhvAhtiAar cGvkk..skAellPhdKere isaLka..........sgmm VaMVGDGvNDAPALAsAdvG iAiG.aGsDiAvesADvvLm rn......cirdvvtlvdLs iaTvrnmkqNlfwAffYNtl gvPlAaglgypffglrltPm lAa.aamslSsvsVlcNalr Lnqfqsssp........... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
  38   P74512    Synechocystis PCC6803                 slr1950           .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........mvqlsptpa stltykdangqnrtasltld VgGMkCagCvaaVErqldql tGVtdscVnlvtavavVrye pekiq........pqaiaeh lsqrGFpsqirhghgaipat ............igeketre nvnwgltialvllllsglgh lshfggpmipf......... .................... .fhhpifhwslatlaiaipG reifldgwrgLrf.....gh anMntLvalgtgsAyltsci awawpglg............ .wecffdepvmllgmlllGr tlEskarqkaksalteLlaL qpslArlvgrgedqg..... ..............etgiei pveqvrvGewvqVlPGekiP vDGilvaGktlvDeSllTGE slPVaKnvddaViaGawNqs GaiiiaathigaettlarIi qLVetAQtqKapmqrlaDqv agwfaygvlaialvtlgfwa mvgqslfp............ .......emvadtglsplll alklsvsVLvvaCPCALgLA tPtailvgtslgAeqGiLiK ggniLEilqrttvmaFDKTG TLTqGnlqltdavpvadi.. .............tgiellt laasvEqgtrHPlaqgliss aqg....lellpven..iet eaGqGvqgwyqgd....... .................... .................... .....rllvGnqqwlmeqg. .vmgepqwqtavdqlldqgk TvifvarnqqlqGflalrDt lrpeakatiaqLkqwGia.. ..plllTGDhpaiAqaiAme vGIee..fqAqmtPqaKvak ikamqgfn........pvsv iaMVGDGiNDAPALAqAdvG islsg.atavAmetADvvLm rs......hLsdvlkaltLs rsTvakikqNllwAlgYNll aiPlAagaflpsfaivltPa iAa.ammasSsivVvlNala Lryqfsrslgqdpg...... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
  39   P77894    Mycobacterium tuberculosis            CtpV/Rv0969       .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .........mrvcvtgfnvd avravaieetvsqvtgvhav hayprtasvviwyspelgdt aavlsaitkaqhvpaelvpa raphsagvrgvgvvrkitgg irrmlsrppgvdkplkasrc ggrprgpvrgsaswpgeqnr rerrtwlprvwlalplglla lgssmffgayp......... .................... ..wagwlafaatlpvqfvaG wpilrgavqqara.....lt snMdtLialgtltAfvysty qlfagg.............. ..plffdtsaliiafvvlGr hlEaratgkaseaiskLleL gakeAtllvdgq........ ................ellv pvdqvqvGDlvrVrPGekiP vDGevtdGraavDeSmlTGE svPVeKtaGdrVagatvNld GlltvratavgadtalaqIv rLVeqAQgdKapvqrlaDrv savfvPavigvavatfagwt liaan............... .................pva gmtaavaVLiiaCPCALgLA tPtaimvgtgrgAelGiLvK ggevLEaskkidtvvFDKTG TLTrarmrVtdviagqrr.. .............qpdqvlr laaavEsgSeHPigaAIvaa aherg....laipaanafta vaGhGvraqvngg....... .................... .................... .....pvvvGrrklvdeqh. .lvlpdhlaaaaveqeergr TavfvgqdgqvvGvlavaDt vkddaadvvgrLhamGlq.. ..vamiTGDnartAaaiAkq vGIek..vlAevlPqdKvae vrrLqd..........qgrv VaMVGDGvNDAPALvqAdlG iAiG.tGtDvAieasDitLm sg......rLdgvvraieLs rqTlrtiyqNlgwAfgYNta aiPlAalga.......lnPv vAg.aamgfSsvsVvtNslr Lrrfgrdgrta......... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
  40   P46840    Mycobacterium leprae                  CtpB              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..................mt aslvedtnnnhesvrriqld VaGMlCaaCasrVEtklnki pGVra.sVnfatrvatIdav d.vav.........delrqv IeqaGYratahaesaveei. ............dpdadyar nllrrlivaallfvpladls tmfaivptnrfp........ .................... ..gwgylltalaapivtwaa wpfhrvalrnary.....ra asMetLisagilaAtgwsls tifvdkeprqthgiwqailh sdsiyfevaagvtvfvlaGr ffEarakskagsalraLaar gaknvevllpnga....... ................elti pagelkkqqhflVrPGetit aDGvvidGtatiDmSaiTGE arPVhaspastVvgGttvld Grlvieatavggdtqfaamv rLVedAQvqKarvqhlaDri aavfvPmvfviaglagaswl lagas............... .................pdr afsvvlgVLviaCPCtLgLA tPtammvasgrgAqlGifiK gyraLEtinaidtvvFDKTG TLTlGqlsVstvtstggw.. .............csgevla lasavEaaSeHsvatAIvaa ya........dprpvadfva faGcGvsgvvaeh....... .................... .................... .....hvkiGkpswvtrnap c...dvvlesarrrrritge TvvfvsvdgvacGavaiaDt vkdsaadaisaLcsrGlh.. ..tillTGDnqaaAravAaq vGIdt..viAdmlPeaKvdv iqrLrd..........qght VaMVGDGiNDgPALAcAdlG lAmG.rGtDvAigaADliLv rd......sLgvvpvaldLa raTmrtiriNmiwAfgYNva aiPiAssgl.......lnPl iAg.aamafSsffVvsNslr Lsnfglsqtsd......... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........
  41   Q10876    Mycobacterium tuberculosis            CtpA/Rv0092       .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .mttavtgehhasvqriqlr IsGMsCsaCahrVEstlnkl pGVr.aaVnfgtrvatIdts eavda.........aalcqa VrraGYqadlctddgrsas. ............dpdadhar qllirlaiaavlfvpvadls vmfgvvpatrft........ .................... ..gwqwvlsalalpvvtwaa wpfhrvamrnarh.....ha asMetLisvgitaAtiwsly tvfgnhspiersgiwqallg sdaiyfevaagvtvfvlvGr yfEaraksqagsalraLaaL sakevavllpdgs....... ................emvi padelkeqqrfvVrPGqiva aDGlavdGsaavDmSamTGE akPtrvrpGgqVigGttvld Grliveaaavgadtqfagmv rLVeqAQaqKadaqrlaDri ssvfvPavlviaaltaagwl iaggq............... .................pdr avsaalaVLviaCPCALgLA tPtammvasgrgAqlGiflK gyksLEatravdtvvFDKTG TLTtGrlqVsavtaapgw.. .............eadqvla laatvEaaSeHsvalAIaaa tt........rrdavtdfra ipGrGvsgtvsgr....... .................... .................... .....avrvGkpswigsssc h....pnmraarrhaeslge TavfvevdgepcGviavaDa vkdsardavaaLadrGlr.. ..tmllTGDnpesAaavAtr vGIde..viAdilPegKvdv ieqLrd..........rghv VaMVGDGiNDgPALArAdlG mAiG.rGtDvAigaADiiLv rd......hLdvvplaldLa raTmrtvklNmvwAfgYNia aiPvAaagl.......lnPl vAg.aamafSsffVvsNslr Lrkfgryplgcgtvggpqmt apssa............... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  42   Q10877    Mycobacterium tuberculosis            CtpB/Rv0103c      .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... maapvvgdadlqsvrrirld VlGMsCaaCasrVEtklnki pGVr.asVnfatrvatIdav g.maa.........delcgv VekaGYhaaphtettvldkr tk..........dpdgahar rllrrllvaavlfvpladls tlfaivpsarvp........ .................... ..gwgyiltalaapvvtwaa wpfhsvalrnarh.....rt tsMetLisvgivaAtawsls svfgdqppregsgiwrailn sdsiylevaagvtvfvlaGr yfEarakskagsalraLaeL gaknvavllpdga....... ................elvi paselkkrqrfvtrPGetia aDGvvvdGsaaiDmSamTGE akPVraypaasVvgGtvvmd Grlvieatavgadtqfaamv rLVeqAQtqKaraqrlaDhi agvfvPvvfviaglagaawl vsgag............... .................adr afsvtlgVLviaCPCALgLA tPtammvasgrgAqlGifiK gyraLEtirsidtvvFDKTG TLTvGqlaVstvtmagsg.. .........tserdreevlg laaavEsaSeHamaaAIvaa sp........dpgpvngfva vaGcGvsgevggh....... .................... .................... .....hvevGkpswitrttp ch..daalvsarldgesrge TvvfvsvdgvvraaltiaDt lkdsaaaavaaLrsrGlr.. ..tillTGDnraaAdavAaq vGIds..avAdmlPegKvdv iqrLre..........eght VaMVGDGiNDgPALvgAdlG lAiG.rGtDvAlgaADiiLv rd......dLntvpqaldLa raTmrtirmNmiwAfgYNva aiPiAaagl.......lnPl iAg.aamafSsffVvsNslr Lrnfgaq............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  43   P46839    Mycobacterium leprae                  CtpA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .............mqriqln ItGMsCscCapngwnnlpnk lsdfstlVnsatrvarltsa rsprp.........lryvka Vrraalctdggealqrr... ............qadadnar yllirlavaaalfvplahls vmfavlpsthfp........ .................... ..gwewmltalaipvvtwaa wpfhrvaihnary.....hg asMetListgitaAtiwsly tvfghhqstehrgvwrallg sdaiyfevaagitvfvlaGk yytarakshasiallaLaaL sakdAavlqpdgs....... ................emvi panelneqqrfvVrPGqtia aDGlvidGsatvsmSpiTGE akPVrvnpGaqVigGtvvln Grliveaaavgdetqlagmv rLVeqAQqqnanaqrlaDri asvfvPcvfavaaldrcwma drrer............... .................trp svlgaiaVLviaCPCALgLA tPtammvasgrgAqlGiLlK ghesfEatravdtvvFDKTG TLTtGqlkVsavtaapgw.. .............qanevlq maatvEsaSeHavalAIaas tt........hrepvanfra vpGhGvsgtvaer....... .................... .................... .....avrvGkpswiasrcn s....ttlvtarrnaelrge TavfveidgeqcGviavaDa vkasaadavaaLhdrGfr.. ..tallTGDnpasAaavAsr iGIde..viAdilPedKvdv ieqLrd..........rghv VaMVGDGiNDgPALArAdlG mAiG.rGtDvAigaADiiLv rd......nLdvvpitldLa aaTmrtikfNmvwAfgYNia aiPiAaagl.......lnPl vAg.aamafSsffVvsNslr Lrnfg.ailscgtsrhrtvk rwrcppptrlrstacspvda splrpvahrtgvkppthr.. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O59666    Schizosaccharomyces pombe             SPBC29A3.01       .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............mytttl sVqGMtCtsCvasIqsmleg veGIeqftIsllleraiavh dpsiis.pdqiaekIedcGF dasvisstege.hgvmanyl llspmqaeqwtkvhnhinel qgvlsvncssspdaairviy dseitg.......prsimke ilsmgvkctfqpvdsstsri ls.........vlqrgsqir .wkirfiisisfslavmflp qifdscdsmraaflvp.... ................hyfg icaghiislvlslpvqfgvG rvyysaayhaLkr.....gt anMdvLvslgstvAfaasif fmilysarhadn........ papiffdtadmlltfvtlGr ylEskakgstsaalsqLlsL apssAtiiedne........ ................qiei ladlierGDlilVkPGeiiP vDGtvveGssyvDeSsvsGE pvPVhKtiddellsGtaNgn GrllvkatkspresqlavIv dLVqrAQishapiqqfaDrv agifvPvivalsistftfwf lftkysskypsvfddpmg.. ................kfav clkltisVvvvaCPCALgLs tPtavmvgtgvgAlnGiiiK ggeiLErlnqvdtvvFDKTG TLTvGklsVtdisivdn... ......leelldipknifwa fvkasEssSeHPigkAItek aseft...dvseigiesfna vpGeGvdvvlrwker..... .................... .................... ...tfhallGnslllehnn. .vsipddfdsklklssssgl TcvriaidgqfvGflgcmDq vrpdsyqtvsaLkqlGkk.. ..vcllTGDqkatArrvAqg leIdfsdvyAeavPsqKaei iqkLkd..........qkhc VaMVGDGiNDsPsLvlAdvG iApi.nGsgiAlesADviLv rkg.....vLldtavsfdLs rvivkrikmNlvwAciYNfv miPiAmgfflpwg.iylnPm wAs.aammfSslsVlassll Lrrwkkpkslifseaddvet esstnssvlqkvytatrsif grnkssnkyqpvanev.... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  44   Q59688    Proteus mirabilis                                       .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .....mntpttlssanrlsl pVeGMtCasCvgrVEralka vpeIkdavVnlateradItf sstpnp..vlavsaIessGY kvpeei..........tela IeeMtCasCvgrVEkalaqi pGVleatVnlaterarVrhl sgvvs........itdleva VvhaGYkprrlsdnpant.. .......kearsrdlseerr elrralliatiftlpvfvie mgshfipgvhh......... ............wvtqtlgq qlnw.yiqfvlativmfgpG lrffkkgipaLlr.....ga pdMnsLvsvgtvaAygysvv stfipqvlpag......... taniyfeaavvivtlillGr nlEakakgntsqaikrLvgL qaktArvsrhge........ ................ilei pldqvmmGDivvVrPGekiP vDGevveGhsyvDeSmiTGE pvPVaKeiGaeVvgGtiNkt GtfsfkvtkvgantilaqIi rLVeeAQgsKlpiqalvDkv tmwfvPavmigatitffiwl afg................. .............pepaltf alinavaVLiiaCPCAmgLA tPtsimvgtgraAelGiLfr kgeaLqalrdvsvvalDKTG TLTkGrpeltdlipae.... ...........kfeyneils lvasiEtySeHPiaqsIvna an....eakltlasvdnfea ipGfGvsatvd......... .................... .................... ...grsvsvGadrfmkql.. .gldvsqfassaqklgeqgk TplytaidgrlaaiiavaDp ikettpeaikaLhalGlk.. ..vamiTGDnkatAkaiAkq lGIde..ivAevlPdgKvaa lkqLsq..........kgdk VafVGDGiNDAPALAqAdvG lAiG.tGtDvAieaADvvLm sg......dLrgvvdaiaLs qaTirnikqNlfwtfaYNal liPvAagmlypingmllsPi fAa.aamalSsvfVlgNalr Lkrfqapmkth......... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O27578    Methanobacterium thermoautotrophicum  MTH1535           .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............mkriti rIgGMgCaaCalkIEealrk ldGIrdaaVnlvegkvsVey dprrvd.lsdmeaaIedaGY tvlnen..........iama VgGMsCamCvqkIEsalrgl eGVsnatVnlaaekayIsyn pslts........vedlkrt VedlGYtvrglegeei.... ...............sedlk pkirriivgfgvsvplmamm ylglqppgg........... .................... ....gismllvsiipfiyvs gpifrgalrsLrs.....gt ldMdvmysmgigvAflssil gtagilp............. sdfmfydtalmlasfltlGr ylEagargktseavrrLmeL qpdtAtvlrdgr........ ................evev riheidvGDeviVrPGdrvP aDGkvveGssyvDefmiTGE plPalKtpGseVvaGtiNtd GilrfrvertgdetflsgIi kLVdeAQasKppiqriaDra vsyfiPavllvatsaflfwy lveg................ ...............aglll sitvlisVLvvaCPCALgLA tPtavtagigrgAelGiLiK kgeaLEvsdriscviFDKTG TLTlGrprVtdmvgd..... .................vlg laaalErkSrHPiaaAvter ae....eegvdvpeaedfra ipGmGlegmvdshh...... .................... .................... ......vlaGnralmekyg. .iplehwdp...ekfesdgk TvvivavdgevkGiiavsDe ikpgsaravreLermGig.. ..tamiTGDnrktAeavAre vGIgt..viAevlPqdKatr vaeLre..........rgeg VafVGDGiNDAPALAeAdlG vAvG.sGtDiAreagevvLm gd......dpldvpaalqLa gkvisrirqNifwAfaYNvv liPlAagalyplgivf.rPe yAg.lamalSsvtVvslslt Lrgytpparrlrekqgeg.. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O29777    Archaeoglobus fulgidus                AF0473            .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...................m vkdtyissasktppmertvr VtGMtCamCvksIEtavgsl eGVeevrVnlatetafIrfd ekrid........fetikrv IedlGYgvvdeqaavsae.. ...............vehls rmkrklyvaafagvlllfla hfislp.yed.......... .................... .....fvqllialpaifysG ssifkaafsaLrr.....rt lnMdvmysmgvgaAflasvl stagvlp............. reysfyetsvlllaflllGr tlEaraksrtgeaikkLvgL qaktAvvirdgk........ ................eiav pveevavGDiviVrPGekiP vDGvvveGesyvDeSmisGE pvPVlKskGdeVfgatiNnt GvlkiratrvggetllaqIv kLVedAmgsKppiqrlaDkv vayfiPtvllvaisafiywy fiah................ ...............apllf afttliaVLvvaCPCAfgLA tPtaltvgmgkgAelGiLiK nadaLEvaekvtaviFDKTG TLTkGkpeVtdlvpln.... ............gderellr laaiaErrSeHPiaeAIvkk al....ehgielgepekvev iaGeGvvadg.......... .................... .................... ......ilvGnkrlmedfg. .vavsnevelaleklereak TavivarngrveGiiavsDt lkesakpavqeLkrmGik.. ..vgmiTGDnwrsAeaisre lnldl..viAevlPhqKsee vkkLqa..........k.ev VafVGDGiNDAPALAqAdlG iAvG.sGsDvAvesgDivLi rd......dLrdvvaaiqLs rkTmskikqNifwAliYNvi liPaAagllypifgvvfrPe fAg.lamamSsvsVvaNsll Lrnyvppirrggdsvekivl elsglschhcvarvkkalee agakvekvdlneavvagnke dvdkyikaveaagyqaklrs .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O32220    Bacillus subtilis                     YvgX              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..........mlseqkeiam qVsGMtCaaCaarIEkglkr mpGVtdanVnlatetsnViy dpaetg.taaiqekIeklGY hvvtek..........aefd IeGMtCaaCanrIEkrlnki eGVanapvnfaletvtVeyn pkeas........vsdlkea VdklGYklklkgeqds.... ..........eaaakkkeer kqtarlifsavlsfpllwam vshftftsfiw......... .................vpd iflnpwmqfalatpvqfliG wpfyvgaykaLrn.....ks anMdvLvalgttaAyaysly ltfqsigshg.........h tdglyyetsailltlillGk lfEtkakgrssdaikkLmkL qaktAtvvrdgq........ ................eqii pidevlvnDivyVkPGeriP vDGevveGrsavDeSmiTGE slPVdKnpGdsVtgstvNan GflkikavnvgkdtalshIi kiVeeAQgsKapiqrlaDqi sgifvPivlgiavltfliwy lwa................. .............apgdfae aiskfiaVLviaCPCALgLA tPtsimagsgraAefGiLfK ggehLEkthrldtivlDKTG TvTnGkprltdaipfg.... ...........rfeekdllq faaaaEtgSeHPlgeAIiag vk....dkgleipkltrfea kvGaGilaeag......... .................... .................... ...gksilvGtrklmese.. .qvehgallaqmeeleaegk TvmlvsidgeaaGlvavaDt ikdtsrkavarLkelGld.. ..vimmTGDnrrtAeaiAke aGIan..iiAevlPeqKaae iarLqk..........egrq taMVGDGiNDAPALAtAdiG mAiG.tGtDiAmetADitLi rg......dLnsiadairms rlTmknikqNlfwAlgYNsl giPiAalgf.......laPw iAg.aamafSsvsVvlNalr Lqkvk............... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  45   P73241    Synechocystis PCC6803                 sll1920           .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ............maqtinlq leGMrCaaCassIEraiakv pGVqscqVnfaleqavVsyh .gett........pqiltda VeraGYharvlkqqvlss.. ........qqtedrkpvfsa klvtglvisavlffgslpmm lg.vniphfph......... .................... ifhdpwlqwllatpvqfwsG aefyrgawksvrt.....rs atMdtLvalgtsaAyfysva itlfpqwltsqg.......l aahvyfeaaavvitlillGr slEqrarretsaairkLmgL qpqtAlvkrgeh........ ................wetv aiaelainDvvrVrPGekiP vDGvvvaGnstvDeSlvTGE sfPVdKtvGteVigatlNks GsldiqvsklgqdsvlaqIi qLVqqAQasKapiqhfvDri thwfvPtvivvaiaafciww ltt................. ...............gnitl avltlveVLiiaCPCALgLA tPtsvmvgtgkgAeyGvLiK eassLEmaekltaivlDKTG TLTqGkpsVtnfftlspt.. ..........steeslqliq waasvEqySeHPlaeAvvny gq....sqqvslleidnfqa iaGcGvagqwq......... .................... .................... ...gqwirlGtsnwltdlgv tgtehqpwqsqaqqwekeqk TviwlavdtevkallaiaDa ikpsspqvvqaLkklGls.. ..vymlTGDnqatAqaiAdt vGIrh..vlAqvrPgdKaqq veqLqq..........kgni VaMVGDGiNDAPALAqAdvG iAiG.tGtDvAiaasDitLi ag......dLqgiltaikLs raTmgnirqNlffAfiYNvi giPvAaglfyplfglllnPi lAg.aamafSsvsVvtNalr Lkkfcp.............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  46   P37279    Synechococcus PCC7942                 PacS              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ............mvnqqtlt lrGMgCaaCagrIEaliqal pGVqecsVnfgaeqaqVcyd paltq........vaaiqaa IeaaGYhafplqdpwdne.. ..veaqerhrrarsqrqlaq rvwvsgliasllvigslpmm lg.isipgipm......... .................... wlhhpglqlgltlpv.lwaG rsffinawkafrq.....nt atMdtLvavgtgaAflysla vtlfpqwltrqg.......l ppdvyyeaiaviiallllGr slEerakgqtsaairqLigL qaktArvlrqgq........ ................eltl pitevqveDwvrVrPGekvP vDGevidGrstvDeSmvTGE slPVqKqvGdeVigatlNkt GsltiratrvgretflaqIv qLVqqAQasKapiqrlaDqv tgwfvPaviaiailtfllwf nwi................. ...............gnvtl alitavgVmiiaCPCALgLA tPtsimvgtgkgAeyGiLiK saesLElaqtiqtvilDKTG TLTqGqpsVtdflaig.... ..........drdqqqtllg waaslEnySeHPlaeAIvry ge....aqgitlstvtdfea ipGsGvqgqve......... .................... .................... ...giwlqiGtqrwlgel.. .gietsalqnqwedweaagk TvvgvaadghlqailsiaDq lkpssvavvrsLqrlGlq.. ..vvmlTGDnrrtAdaiAqa vGItq..vlAevrPdqKaaq vaqLqs..........rgqv VaMVGDGiNDAPALAqAdvG iAiG.tGtDvAiaasDitLi sg......dLqgivtaiqLs raTmtnirqNlffAfiYNva giPiAagilypllgwllsPm lAg.aamafSsvsVvtNalr Lrqfqpr............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  47   P77881    Listeria monocytogenes                CtpA              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...................m siknrfiigvigsvpllinm fmsfggsmlgg......... .................... dkygvwilfafgslvywfsG lpflrtavasfkn.....hh anMdtLvglgttiAyvysly amfarp.............. .netyfeavavvitlillGs yfEermkasassavdkLmgL qakdAevlrdge........ ................fikl pieeiivGDlirVkPGekva vDGqiveGtstlDeSmvTGE smPVeKgpGdnVigatlNnt GsftfevtkvgadtmlsnIa emVrhAQnsrapiqktvDri snifvPivlmisiltfivwy vfl................. ..............gstlvt amifsvsVmiiaCPCALgiA tPtalmvgtgrsAklGiLiK naevLEathdiktvvmDKTG TiTvGkpqVtdiisig.... ...........riseneilr iaaglEdsSeHPlalAvine ak....dkkitpavaknfta isGkGvqalid......... .................... .................... ...gkqafiGndrlsddfn. ..mtddlkvkmts.lqaqak TvvlvgydgqiialigiqDa pkssskaairamqksGfh.. ..tvmlTGDnrlvAqaiAdd iGIde..viAdvmPgdKaqh irkLqe..........kg.a VafVGDGiNDAPALstAtvG iAmG.sGsDiAiesggivLv kn......dLmdvvtslvLa rkTysriliNlfwAfiYNvi giPvAagifsalg.ftlsPe lAg.lamalSsitVvlssll Lnyvrlpkssetli...... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  48   P38995    Saccharomyces cerevisiae              CCC2/ydr270w      .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .....mrevilaVhGMtCsa CtntIntqlralkGVtkcdI slvtnecqVtydnevta.ds ikeiIedcGFdceilrdsei ta.................. .................... ............istkegll sVqGMtCgsCvstVtkqveg ieGVesvvVslvteechViy epsktt.letaremIedcGF dsniimdgngn.admtektv ilkvtkafedesplilssvs erfqflldlgvksieisddm htltikyccnelgirdllrh lertgykftvfsnldn.... .....ttqlrllskedeirf wkknsikstllaiicmllym ivpmmwptivqdr....... ........ifpyketsfvrg lfyrdilgvilasyiqfsvG fyfykaawasLkh.....gs gtMdtLvcvsttcAytfsvf slvhnmfhpsstg......k lprivfdtsimiisyisiGk ylEtlaksqtstalskLiqL tpsvcsiisdverne..... ................tkei piellqvnDiveikPGmkiP aDGiitrGeseiDeSlmTGE silVpKktGfpViaGsvNgp GhfyfrtttvgeetklanIi kvmkeAQlsKapiqgyaDyl asifvPgililavltffiwc filnisanppvaftan.... ............tkadnffi clqtatsVvivaCPCALgLA tPtaimvgtgvgAqnGvLiK ggevLEkfnsittfvFDKTG TLTtGfmvVkkflkdsn... ........wvgnvdedevla cikatEsiSdHPvskAIiry cdgln.cnkalnavvlesey vlGkGivskcqvngn..... .................... .................... ...tydiciGnealiledal k......ksgfinsnvdqgn TvsyvsvnghvfGlfeinDe vkhdsyatvqyLqrnGye.. ..tymiTGDnnsaAkrvAre vGIsfenvysdvsPtgKcdl vkkiqdke........gnnk VavVGDGiNDAPALAlsdlG iAis.tGteiAieaADivil cgndlntnsLrglanaidis lkTfkriklNlfwAlcYNif miPiAmgvlipwg.itlpPm lAg.lamafSsvsVvlsslm Lkkwtppdieshgisdfksk fsignfwsrlfstraiageq diesqaglmsneevl..... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  49   Q04656    Homo sapiens                          ATP7A/MNK         mdpsmgvnsvtisVeGMtCn sCvwtIEqqigkvnGVhhik VsleeknatIiydpklqtpk tlqeaIddmGFdavihnpdp lpvltdtlfltvtasltlpw dhiqstllktkgvtdikiyp qkrtvavtiipsivnanqik elvpelsldtgtlekksgac edhsmaqagevvlkmkVeGM tChsCtstIEgkigklqGVq rikVsldnqeatIvyqphli sveemkkqIeamGFpafvkk qpkylklgaidverlkntpv k........ssegsqqrsps ytndstatfiIdGMhCksCv snIEstlsalqyVssivVsl enrsaiVkynassvtpeslr kaIeavspglyrvsitseve stsnsp..sssslqkiplnv vsqpltqetvinIdGMtCns CvqsIEgviskkpGVksirV slansngtVeydplltspet lrgaIedmGFdatlsd.... ..........tneplvviaq pssemplltstnefytkgmt pvqdkeeg....knsskcyi qVtGMtCasCvanIErnlrr eeGIysilValmagkaeVry npaviq.ppmiaefIrelGF gatvienade..gdgvlelv VrGMtCasCvhkIEssltkh rGIlycsValatnkahIkyd peiig........prdiiht IeslGFeaslvkkdrs.... ........ashldhkreirq wr.rsflvslffcipvmglm tymmvmdhhfatlhhnqnms keeminlhssmflerqilpg lsvmnllsfllcvpvqffgG wyfyiqaykaLkh.....kt anMdvLivlattiAfaysli illvamyerak........v npitffdtppmlfvfialGr wlEhiakgktsealakLisL qateAtivtldsdni..... .............llseeqv dvelvqrGDiikVvPGgkfP vDGrvieGhsmvDeSliTGE amPVaKkpGstViaGsiNqn GsllicathvgadttlsqIv kLVeeAQtsKapiqqfaDkl sgyfvPfivfvsiatllvwi vigflnfeivetyf...... ....pgynrsisrtetiirf afqasitVLciaCPCsLgLA tPtavmvgtgvgAqnGiLiK ggepLEmahkvkvvvFDKTG TiThGtpvVnqvkvltes.. ..........nrishhkila ivgtaEsnSeHPlgtAItky ck..qeldtetlgtcidfqv vpGcGisckvtniegllhkn nwniednniknaslvqidas neqsstsssmiidaqisnal naqqhkvliGnrewmirng. .lvinndvndfmteherkgr TavlvavddelcGliaiaDt vkpeaelaihiLksmGle.. ..vvlmTGDnsktArsiAsq vGItk..vfAevlPshKvak vkqLqe..........egkr VaMVGDGiNDsPALAmAnvG iAiG.tGtDvAieaADvvLi rn......dLldvvasidLs rkTvkririNfvfAliYNlv giPiAagvfmpig.lvlqPw mgs.aamaaSsvsVvlsslf Lklyrkptyesyelparsqi gqkspseisvhvgiddtsrn spklglldrivnysrasins llsdkrslnsvvtse.pdkh sllvgdfredddtal..... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
 (49)  P49015    Cricetulus griseus                    ATP7A             mepsmdvnsvtisVeGMtCi sCvrtIEqkigkenGIhhik VsleeksatIiydpklqtpk tlqeaIddmGFdallhnanp lpvltdtlfltvtasltlpw dhiqstllktkgvtdikifp qkrtlavtiipsivnanqik elvpelsletgtlekrsgac edhsmaqagevvlkikVeGM tChsCtsttEgkigklqGVq rikVsldnqeatIvyqphli sveeikkqIeamGFpafvkk qpkylklgaidverlkntpv k........slegsqqr.ps ypsdstatfiIeGMhCksCv snIEsalptlqyVssiaVsl enrsaiVkynassvtpemli kaIeavspgqyrvsianeve stsssp..sssslqkmplnv vsqpltqetvinIsGMtCns CvqsIEgvvskkpGVksihV slansfgtVeydplltapet lrevIvdmGFdavlpd.... ..........mseplvviaq psletpllpstndq.dnmmt a............vhskcyi qVsGMtCasCvanIErnlrr eeGIysvlValmagkaeVry npaviq.ppviaefIrelGF gatvmenade..gdgilklv VrGMtCasCvhkIEstltkh kGIfycsValatnkahIkyd peiig........prdiiht IgslGFeaslvkkdrs.... ........ashldhkreikq wr.ssflvslffctpvmglm mymmamehhfatihhnqsms neemiknhssmflerqilpg lsimnllslllclpvqffgG wyfyiqaykaLkh.....kt anMdvLivlattiAfaysli illvamyerak........v npitsfdtppmlfvfialGr wlEhiakgktsealakLisL qateAtivtldsdni..... .............llseeqv dvelvqrGDiikVvPGgkfP vDGrvieGhsmvDeSliTGE amPVaKkpGstViaGsiNqn GsllicathvgadttlsqIv kLVeeAQtsKapiqqfaDkl ggyfvPfivlvsiatllvwi iigfqnftivetyf...... ....pgysrsisrtetiirf afqasitVLciaCPCsLgLA tPtavmvgtgvgAqnGiLiK ggepLEmahkvkvvvFDKTG TiThGtpvVnqvkvlves.. ..........nkiprskila ivgtaEsnSeHPlgaAvtky ck..qeldtetlgtctdfqv vpGcGisckvtniegllhks nlkieenntknaslvqidai neqsstsssmiidaplsnav dtqqykvliGnrewmirng. .lvisndvddsmidhgrkgr pavlvtiddelcGliaiaDt vkpeaelavhiLksmGle.. ..vvlmTGDnsktArsiAsq vGItk..vfAevlPshKvak vkqLqe..........egkr VaMVGDGiNDsPALAmAnvG iAiG.tGtDvtieaADvvfi rn......dLldvvasidLs rkTvkririNflfpliYNlv giPiAagvflpig.lvfqPw mgs.aamaaSsvsVvlsslf Lklyrkptydnyelrtrsht gqrspseisvhvgiddasrn sprlglldrivnysrasins llsdkrslnsvvnse.pdkh s................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
 (49)  Q64430    Mus musculus                          ATP7A/MNK         mepsvdansititVeGMtCi sCvrtIEqqigkvnGVhhik VsldeksatIiydpklqtpk tlqeaIddmGFdallhnanp lpvltntvfltvtapltlpw dhvqstllktkgvtgvkisp qqrsavvtiipsvvsasqiv elvpdlsldmgtqekksgac eehstpqagevrlkmkVeGM tChsCtstIEgkvgklqGVq rikVsldnqeatIvfqphli taeeikkqIeavGFpafikk qpkylklgaidverlkntpv k........ssegsqqksps ypsdsttmftIeGMhCksCv snIEsalstlqyVssivVsl enrsaiVkynaslvtpemlr kaIeaispgqyrvsiaseve stassp..sssslqkmplni vsqpltqeavinInGMtCns CvqsIEgviskkpGVksihV slanstgtIefdplltspet lreaIedmGFdaalpd.... ..........mkeplvviaq psletpllpssnel.envmt s............vqnkcyi qVsGMtCasCvanIErnlrr eeGIysvlValtagkaeVry npaviq.prviaefIrelGF gamvmenage..gngilelv VrGMtCasCvhkIEstltkh kGIfycsValatnkahIkyd peiig........prdiiht IgslGFeaslvkkdrs.... ........anhldhkreikq wr.gsflvslffcipvmglm vymmvmdhhlatlhhnqnms neeminmhsamflerqilpg lsimnllslllclpvqfcgG wyfyiqaykaLkh.....kt anMdvLivlattiAfayslv illvamferak........v npitffdtppmlfvfialGr wlEhiakgktsealakLisL qateAtivtlnsenl..... .............llseeqv dvelvqrGDiikVvPGgkfP vDGrvieGhsmvDeSliTGE amPVaKkpGstViaGsiNqn GsllirathvgadttlsqIv kLVeeAQtsKapiqqfaDkl sgyfvPfivlvsivtllvwi iigfqnfeivetyf...... ....pgynrsisrtetiirf afqasitVLciaCPCsLgLA tPtavmvgtgvgAqnGiLiK ggepLEmahkvkvvvFDKTG TiThGtpvVnqvkvlves.. ..........nkisrnkila ivgtaEsnSeHPlgaAvtky ck..keldtetlgtctdfqv vpGcGisckvtniegllhks nlkieenniknaslvqidai neqsstsssmiidahlsnav ntqqykvliGnrewmirng. .lvisndvdesmieherrgr TavlvtiddelcGlmaiaDt vkpeaelavhiLksmGle.. ..vvlmTGDnsktAqsiAsq vGItk..vfAevlPshKvak vkqLqe..........egkr VaMVGDGiNDsPALAmAnvG iAiG.tGtDvAieaADvvLi rn......dLldvvasidLs rkTvkririNfvfAliYNlv giPiAagvflpig.lvlqPw mgs.aamaaSsvsVvlsslf Lklyrkptydnyelhprsht gqrspseisvhvgiddtsrn sprlglldrivnysrasins llsdkrslnsvvtse.pdkh sllvgdfredddttl..... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
 (49)  P70705    Rattus norvegicus                     ATP7A/MNK         mepnmdansititVeGMtCi sCvrtIEqqigkvnGVhhik VsleeksatViynpklqtpk tlqeaIddmGFdallhnanp lpvltntvfltvtaplalpw dhiqstllktkgvtgvkisp qqrsavvtiipsvvsanqiv elvpdlsldmgtqekksgts eehstpqagevllkmrVeGM tChsCtstIEgkvgklqGVq rikVsldnqeatIvyqphli taeeikkqIeavGFpafikk qpkylklgaidverlkstpv k........ssegsqqkspa ypsdsaitftIdGMhCksCv snIEsalstlqyVssivVsl enrsaiVkynaslvtpeilr kaIeavspgqyrvsisseve sptssp..sssslqkmplnl vsqpltqevvinInGMtCns CvqsIEgviskkpGVksihV sltnstgtIeydplltspep lreaIedmGFdavlpa.... .........dmkeplvviaq psletpllpsttep.envmt p............vqnkcyi qVsGMtCasCvanIErnlrr eeGIysvlValmagkaeVry npaviq.prviaelIrelGF gavvmenage..gngilelv VrGMtCasCvhkIEstltkh kGIfycsValatnkahIkyd peiig........prdiiht IgnlGFeaslvkkdrs.... ........anhldhkreikq wr.gsflvslffcipvmglm iymmvmdhhlatlnhnqnms neeminmhssmflerqilpg lsimnllslllclpvqfcgG wyfyiqaykaLrh.....kt anMdvLivlattiAfayslv illvamyerak........v npitffdtppmlfvfialGr wlEhiakgktsealakLisL qateAtivtlnsenl..... .............llseeqv dvelvqrGDiikVvPGgkfP vDGrvieGhsmvDeSliTGE amPVaKkpGstViaGsiNqn GsllirathvgadttlsqIv kLVeeAQtsKapiqqfaDkl sgyfvPfivlvsivtllvwi iigfqnfeiveayf...... ....pgynrsisrtetiirf afqasitVLciaCPCsLgLA tPtavmvgtgvgAqnGiLiK ggepLEmahkvkvvvFDKTG TiThGtpvVnqvkvlves.. ..........nkisrnkila ivgtaEsnSeHPlgaAvtky ck..qeldtetlgtctdfqv vpGcGisckvtniegllhks nlkieenniknaslvqidai neqsspsssmiidahlsnav ntqqykvliGnrewmirng. .lvisndvdesmieherrgr TavlvtiddelcGliaiaDt vkpeaelavhiLksmGle.. ..vvlmTGDnsktArsiAsq vGItk..vfAevlPshKvak vkqLqe..........egkr VaMVGDGiNDsPALAmAsvG iAiG.tGtDvAieaADvvLi rn......dLldvvasidLs rkTvkririNfvfAliYNli giPiAagvflpig.lvlqPw mgs.aamaaSsvsVvlsslf Lklyrkptydnyelrprsht gqrspseisvhvgiddtsrn sprlglldrivnysrasins llsdkrslnsvvtse.pdkh sllvgdfredddttl..... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  50   Q64535    Rattus norvegicus                     ATP7B             .................... ........mpeqerkvtake asrkilsklalptrpwgqsm kqsfafdnvgyeggldstcf ilqlttgvvsIlGMtChsCv ksIEdrisslkGIvsikVsl eqgsatVkyvpsvlnlqqic lqIedmGFeasaaegkaasw psrssp.aqeavvklrVeGM tCqsCvssIEgkirklqGVv rvkVslsnqeavItyqpyli qpedlrdhIcdmGFeaaikn rtaplrlgpidinklestnl kraavppiqnsnhletpghq qnhlatlplrIdGMhCksCv lnIEgnigqlpGVqnihVsl enktaqVqydsscitplflq taIealppgyfkvslpdgle kesgss..svpslgssqrqq epgp.crtavltitgiprds svqpmedmlsqmkgvqqidi slaegtgavlydpsvvssde lrtavedmgfevsvnpenit tnrvs...sgnsvpqavgds pgsvqnmasdtrgllthqgp gylsdsppspggtasqkcfv qIkGMtCasCvsnIErslqr haGIlsvlValmsgkaeVky dpeviq.spriaqlIedlGF eaaimedntv..segdieli ItGMtCasCvhnIEskltrt nGItyasValatskahVkfd peiig........prdiikv IeeiGFhaslahrnpn.... ........ahhldhkteikq wk.ksflcslvfgipvmglm iymlipsskph......... ........etmvldhniipg lsvlnliffilctfvqflgG wyfyvqayksLrh.....ks anMdvLivlattiAyayslv ilvvaiaekae........k spvtffdtppmlfvfialGr wlEhvaksktsealakLmsL qateAtvvtlgednl..... .............ilreeqv pmelvqrGDiikVvPGgkfP vDGkvleGntmaDeSliTGE amPVtKkpGsiViaGsiNah GsvlikathvgndttlaqIv kLVeeAQmsKapiqqlaDrf sgyfvPfiiiistltlvvwi iigfvdfgivqkyf...... ....pspskhisqteviirf afqtsitVLciaCPCsLgLA tPtavmvgtgvaAqnGvLiK ggkpLEmahkiktvmFDKTG TiThGvprVmrflllvdv.. ..........atlslrkvla vvgtaEasSeHPlgvAvtky ck..eelgtetlgystdfqa vpGcGisckvsnvesilahr ...............gptah pigvg.......nppigegt gpqtfsvliGnrewmrrng. .ltissdisdamtdhemkgq TailvaidgvlcGmiaiaDa vkpeaalasitLksmGvd.. ..valiTGDnrktAraiAtq vGInk..vfAevlPshKvak vqeLqn..........kgkk VaMVGDGvNDsPALAqAdvG iAiG.tGtDvAidaADvvLi rn......dLldvvasihLs krTvrrirvNlvlAliYNmv giPiAagvfmpig.ivlqPw mg...saaaSsvsVvlsslq Lkcyrkpdleryeaqahgrm kplsasqvsvhvgmddrrrd spratpwdqvsyvsqvslss ltsdrlsrhggmaedggdkw slllsdrdeeqci....... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  51   P35670    Homo sapiens                          ATP7B/WND         .................... .......mpeqerqitareg asrkilsklslptrawepam kksfafdnvgyeggldglgp ssqvatstvrIlGMtCqsCv ksIEdrisnlkGIismkVsl eqdsatVkyvpsvvclqqvc hqIgdmGFeasiaegkaasw psrslp.aqeavvklrVeGM tCqsCvssIEgkvrklqGVv rvkVslsnqeavItyqpyli qpedlrdhVndmGFeaaiks kvaplslgpidierlqstnp krplssanqnfnnsetlghq gshvvtlqlrIdGMhCksCv lnIEenigqllGVqsiqVsl enktaqVkydpsctspvalq raIealppgnfkvslpdgae gsgtdhrsssshspgspprn qvqgtcsttliaIaGMtCas CvhsIEgmisqleGVqqisV slaegtatVlynpsvispee lraaIedmGFeasvvsescs tnplgnhsagnsmvqttdgt ptsvqevaphtgrlpanhap dilakspqstravapqkcfl qIkGMtCasCvsnIErnlqk eaGVlsvlValmagkaeIky dpeviq.pleiaqfIqdlGF eaavmedyag..sdgnielt ItGMtCasCvhnIEskltrt nGItyasValatskalVkfd peiig........prdiiki IeeiGFhaslaqrnpn.... ........ahhldhkmeikq wk.ksflcslvfgipvmalm iymlipsneph......... ........qsmvldhniipg lsilnliffilctfvqllgG wyfyvqayksLrh.....rs anMdvLivlatsiAyvyslv ilvvavaekae........r spvtffdtppmlfvfialGr wlEhlaksktsealakLmsL qateAtvvtlgednl..... .............iireeqv pmelvqrGDivkVvPGgkfP vDGkvleGntmaDeSliTGE amPVtKkpGstViarsiNah GsvlikathvgndttlaqIv kLVeeAQmsKapiqqlaDrf sgyfvPfiiimstltlvvwi vigfidfgvvqkyf...... ....pnpnkhisqteviirf afqtsitVLciaCPCsLgLA tPtavmvgtgvaAqnGiLiK ggkpLEmahkiktvmFDKTG TiThGvprVmrvlllgdv.. ..........atlplrkvla vvgtaEasSeHPlgvAvtky ck..eelgtetlgyctdfqa vpGcGigckvsnvegilahs erpls..........apash lneag.......slpaekda vpqtfsvliGnrewlrrng. .ltissdvsdamtdhemkgq TailvaidgvlcGmiaiaDa vkqeaalavhtLqsmGvd.. ..vvliTGDnrktAraiAtq vGInk..vfAevlPshKvak vqeLqn..........kgkk VaMVGDGvNDsPALAqAdmG vAiG.tGtDvAieaADvvLi rn......dLldvvasihLs krTvrririNlvlAliYNlv giPiAagvfmpig.ivlqPw mgs.aamaaSsvsVvlsslq Lkcykkpdleryeaqahghm kpltasqvsvhigmddrwrd spratpwdqvsyvsqvslss ltsdkpsrhsaaadddgdkw slllngrdeeqyi....... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
 (51)  Q64446    Mus musculus                          ATP7B/WND         ................mdpr knlasvgtmpeqerqvtake asrkilsklalpgrpweqsm kqsfafdnvgyeggldstss s.paatdvvnIlGMtChsCv ksIEdrisslkGIvnikVsl eqgkhtVryvpsvmnlqqic lqIedmGFeasaaegkaasw psrssp.aqeavvklrVeGM tCqsCvssIEgkirklqGVv rikVslsnqeavItyqpyli qpedlrdhIcdmGFeaaikn rtaplrlgpidvnklestnl kketvspvqisnhfetlghq gsylatlplrIdGMhCksCv lnIEgnigqlpGVqnihVsl enktaqIqydpscvtpmflq taIealppghfkvslpdgve ene........pqsgssqrh qeqgpgrtavltIsGitCas svqpIEdmlsqrkGVqqtsI slaegtgaVlydpsivslde lrtaVedmGFevsvnsetft inpvrnfksgnsvpqtmgdi agsvqkmapdtrglpthqgp ghssetpsspgatasqkcfv qIkGMtCasCvsnIErslqr haGIlsvlValmsgkaeVky dpeiiq.spriaqlIqdlGF easvmedntv..segdieli ItGMtCasCvhnIEskltrt nGItyasValatskahVkfd peivg........prdiiki IeeiGFhaslaqrnpn.... ........ahhldhkteikq wk.ksflcslvfgipvmglm vymlipsstpq......... ........etmvldhniipg lsvlnliffilctfvqflgG wyfyvqayksLrh.....rs anMdvLivlattiAyayslv ilvvavaekae........k spvtffdtppmlfvfialGr wlEhvaksktsealakLmsL qateAtvvtlgednl..... .............ilreeqv pmelvqrGDvikVvPGgkfP vDGkvleGntmaDeSliTGE amPVtKkpGsiViaGsiNah GsvllkathvgndttlaqIv kLVeeAQmsKapiqqlaDrf sgyfvPfiiiistltlvvwi vigfvdfgvvqkyf...... ....pspskhisqteviirf afqtsitVLciaCPCsLgLA tPtavmvgtgvaAqnGvLiK ggkpLEmahkiktvmFDKTG TiThGvprVmrfllladv.. ..........atlplrkvla vvgtaEasSeHPlgvAvtky ck..eelgtetlgystdfqa vpGcGisckvsnvegilars ...............dltah pvgvg.......npptgega gpqtfsvliGnrewmrrng. .ltissdisdamtdhemkgq TailvaidgvlcGmiaiaDa vkpeaalaiytLksmGvd.. ..valiTGDnrktAraiAtq vGInk..vfAevlPshKvak vqeLqn..........egkk VaMVGDGvNDsPALAqAdvG iAiG.tGtDvAieaADvvLi rn......dLldvvasihLs krTvrrirvNlvlAliYNmv giPiAagvfmpig.ivlqPw mgs.aamaaSsvsVvlsslq Lkcyrkpdleryeaqahgrm kplsasqvsvhigmddrrrd spratawdqvsyvsqvslss ltsdrlsrhggaaedggdkw slllsdrdeeqci....... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   Q9XT50    Ovis aries                            ATP7B             .................... ............mkpeeerp iidrekasrrilsklfqpam kqsfafdnngyeddldgvcp s.qtaagtisIvGMtCqsCv ksIEgrvsslkGIvsikVsl eqssaeVryvpsvvslmqic hqIedmGFqasvaegkatsw asrvsp.tseavvklrVeGM tCqsCvssIEgkigklqGVm rvrVslsnqeavItyqpyli qpqdlrdhItdmGFeavikn kvapvslgpidvrrlqstls vappapvnqndnnsetpggq g...vplhlrVdGMhCksCv lnIEdnigqlpGVqsihVsl esrtarVqynpslvspgalr raIealppgnfkvsfpngae gsg..........pdsrtpp apsapc.tmmlaIaGMtCks CvqsIEglisqrvGVhqisV flaegtavVlydpsrthpee lraaVedmGFeasilaencs snqvgnhsagsavgpeaaga pvpmqgeapqpgglhtnhip hqspksllasttvapkkcfl qIsGMtCasCvsnIErnlqk epGIlsvlValmagkaeVky npeaiq.pleiaklVqdlGF eaavmedytg..sdgdlelm ItGMtCasCvhnIEsklrrt eGItyasValatskahVkfd peiig........prdivkl IeeiGFraslaqripn.... ........ahhldhkveikq wk.nsflcslvfgipvmglm iymlipshep.......... ........qssvldhnvipg lsilnliffilctfvqflgG wyfyvqayksLrh.....gm anMdvLivlatsiAyvyslv ilvvavaekae........r spvtffdtppmlfvfialGr wlEhvvksktsealarLmsL qateAtvvtlgednv..... .............iireeqv pmelvqrGDiikVvPGgkfP vDGkvleGntmaDeSliTGE amPVtKkpGsmViaGsmNah GsvlitathvgndttlaqIv kLVeeAQmsKapiqqlaDrf sgyfvPfiiiistvtlvvwi vigfidfgvvqkyf...... ....papskgisqaevvlrf afqtsitVLciaCPCsLgLA tPtavmvgtgvaAqnGiLiK ggkpLEmahkiktvmFDKTG TiThGvpkVsrvlllvdl.. ..........atlplrkvla vvgtaEasSeHPlgvAvtry ck..eelgtetlgccmdfqa vpGcGisckvssvesilaqg erlqg..........pptah qnrvg.......sepsetda atqtfsvliGnrewmrrng. .ltvtsdvrdamtdhetkgq TailvaidgvlcGmiavaDs vkqeaalavhtLksmGvd.. ..vvliTGDnrktAraiAtq vGInk..vfAevlPshKvak vqeLqn..........qgkr VaMVGDGvNDsPALAqAdvG iAiG.tGtDvAieaADvvLi rn......dLldvvasihLs rrTvwrirlNlvlAliYNli giPvAagvfipig.vvlqPw mgs.aamaaSsvsVvlsslq Lkcyrkpdlaryeaqahghm kplsasqvsvrvgmddrrrd sprasawdqvsyvsqvslsp lksdklsrhsgaaddrgdkw slllndrdeeqgi....... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   Q9S7J8    Arabidopsis thaliana                  RAN1/At5g44790    .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...........mapsrrdlq ltpvtggsssqisdmeevgl ldsyhneanaddiltkieeg rdvsglrkiqvgVtGMtCaa CsnsVEaalmnvnGVfkasV allqnradVvfdpnlvkeed ikeaIedaGFeaeilaeeqt .................... .................... ............qatlvgqf tIgGMtCaaCvnsVEgilrd lpGVkravValstslgeVey dpnvin.kddivnaIedaGF egslvqsnqq.......... .............dklvlri dgilneldaqvlegiltrln gvrqfrldrisgelevvfdp evvssrslvdgieedgfgkf klrvmspyerlsskdtgeas nmfrrfisslvlsiplffiq vicphialfd.......... ........allvwrcg...p fmmgdwlkwalvsviqfviG krfyvaawraLrn.....gs tnMdvLvalgtsasyfysvg allygavtgfw........s p..tyfdasamlitfvllGk ylEslakgktsdamkkLvqL tpatAilltegkggk..... .............lvgerei dalliqpGDtlkVhPGakiP aDGvvvwGssyvneSmvTGE svPVsKevdspVigGtiNmh GalhmkatkvgsdavlsqIi sLVetAQmsKapiqkfaDyv asifvPvvitlalftlvgws iggavgaypdewlp...... ............engthfvf slmfsisVvviaCPCALgLA tPtavmvatgvgAtnGvLiK ggdaLEkahkvkyviFDKTG TLTqGkatVtttkvfsem.. ..........d...rgeflt lvasaEasSeHPlakAIvay arhfhffdestedgetnnkd lqnsGwlldtsdfsalpgkg .................... .................iqc lvnekmilvGnrklmsena. .inipdhvekfvedleesgk TgvivayngklvGvmgiaDp lkreaalvvegLlrmGvr.. ..pimvTGDnwrtAravAke vGIed..vrAevmPagKadv irsLqk..........dgst VaMVGDGiNDsPALAaAdvG mAiG.aGtDvAieaADyvLm rn......nLedvitaidLs rkTltrirlNyvfAmaYNvv siPiAagvffpvlrvqlpPw aAg.acmalSsvsVvcssll Lrrykkprlttvlkitte.. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O17737    Caenorhabditis elegans                cua-1             .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..................ms envslldgsplpsrpstssi prpspskniqllvdfgapkt dgnvqetmleIkGMtCnsCv knIqdvigakpGIhsiqvnl keenakcsfdttkwtaekva eaVddmGFdckvlkkepp.. .................tqm aekpkirraivsIeGMtCha CvnnIqdtvgskdGIvkivV sleqkqgtVdynsekwnges vaesIddmGFdcklitdqe. ........iaavepqkastt klsisplktvdlsdgkvelq lngvkyskegssdhlekctf aVeGMtCasCvqyIErnisk ieGVhsivValiaakaeViy dgrvtssdairehmtgelGY katlldsmganpnyskirli ignlstesdanrieshvlsk sgidscnVsiatsmalvefs pqvig........prdiinv veslgftadlatrddq.... ........mkrldhsddvkk wr.ntffialifgvpvmiim iifhwilrtpmhp....... ........dkqtpift..pa lsldnflllclctpvqifgG ryfyvaswkaikh.....gn anMdvLimlsttiAytysiv vlllaiifkwp........s spmtffdvppmlivfialGr mlEhkakgktsealskLmsL qakeAtlvtmdsegr..... .............ltsekgi nielvqrnDlikVvPGakvP vDGvvvdGkssvDeSfiTGE smPVvKkpGstVigGsvNqk GvlivkathvgndstlsqIv rLVeeAQtnrapiqqlaDki agyfvPfvivlslftlgvwi yieynsarnan.lp...... .........pglrfeealki afeaaitVLaiaCPCsLgLA tPtavmvgtgvgAanGiLiK ggepLEsvhkvttivFDKTG TiTeGrprVvqiasfvnp.. ..........stmslklitf lsgatEalSeHPignAvaaf ak..qllneptwpntsrfhv saGhGvtcridsirqsfssl alsgstceiprlp..dgqti tipgtevnllqvsskevsqp npdtaniviGtermmerhg. .ipvsevvkmtlseeqrkgh isvicainaevvavisiaDq vkkeaslaiytLremGlr.. ..vvllTGDnsktAestAkq vGIde..vfAevlPnqKqqk ikqLkg..........yknk VaMVGDGvNDsPALAeAnvG iAia.aGsDvAiesAgivLv rn......dLvdvvgaikLs kmTtrrirlNflfAiiYNai giPiAagvfrpfg.fmlqPw mAa.aamalSsvsVvsssll Lknfrkptianlyttsfkrh qkflesgsfqvqvhrgldds avfrgaassklsilsskvgs llgsttsivssgsskkqrll dnvgsdledliv........ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  52   P38360    Saccharomyces cerevisiae              PCA1/ybr295w      .................... .................... .................... .................... .................... ......mkpeklfsglgtsd geygvvnsenisidamqdnr gechrrsiemhandnlglvs qrdctnrpkitpqeclsete qichhgenrtkagldvddae tggdhtnesrvdeccaekvn dtetgldvdsccgdaqtggd htnescvdgccvrdssvmve evtgsceavsskeqlltsfe vvpskseglqsihdirettr cntnsnqhtgkgrlciessd stlkkrsckvsrqkievssk peccniscveriasrscekr tfkgstnvgisgssstdsls ekffseqysrmynryssilk nlgcicnylrtlgkescclp kvrfcsgegaskktkysyrn ssgcltkkkthgdkerlsnd nghadfvcskscctkmkdca vtstisgtssseisrivsme pienhlnleagstgtehivl sVsGMsCtgCesklkksfga lkcVhglktslilsqaefnl dlaqgs.vkdvikhlsktte fkyeqisnhg.......... .................... ....stidvvvpyaakdfin eewpq........gvtelki verniiriyfdpkvigardl vnegwsvpvsiapfschpti evgrkhlvrvgcttalsiil tipilvmawapqlr...... ...................e kistisasmvlatiiqfvia gpfylnalksLifs....rl ieMdlLivlstsaAyifsiv sfgyfvvgrpls........ .teqffetssllvtlimvGr fvselarhravksisvr.sL qassAilvdktgk....... ................etei nirllqyGDifkVlPdsriP tDGtvisGssevDealiTGE smPVpKkcqsiVvaGsvNgt GtlfvklsklpgnntistIa tmVdeAkltKpkiqniaDki asyfvPtiigitvvtfcvwi avgirvekq........... ............srsdaviq aiiyaitVLivsCPCvigLA vPivfviasgvaAkrGvifK saesiEvahntshvvFDKTG TLTeGkltVvhetvrg.... .............drhnsqs lllgltegikHPvsmAIasy lkekg....vsaqnvsntka vtGkrvegtsysg....... .................... .................... ....lklqgGncrwlghn.. .......ndpdvrkaleqgy svfcfsvngsvtavyaleDs lradavstinlLrqrGis.. ..lhilsGDddgavrsmAar lGIessnirshatPaeKsey ikdivegrncdsssqskrpv VvfcGDGtNDAigLtqAtiG vhin.eGsevAklaADvvml kp......kLnniltmitvs qkamfrvklNflwsftYNlf aillAagafvd...fhipPe yAg.lgelvSilpVifvail Lryaki.............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O26033    Helicobacter pylori strain 26695      HP1503            .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .............mkcshcq lefkeselfkevinhkelhf cctgcarvyallldlnlesf ydklndstlapvtpqdsmsa leleqaleennkgdfilnll lekthCnaClwlnqkvlerl sGVkkvsVnftthhlqIvfe kslnp.........keiiqk IeslGYgakiynaqn..... ..........ytlkaqkeqr sylltlsvgffatmnlmfia iakyasyggasygg...... .........anygagmdklm qrnldlvslflsllvlvvvG rffikgafygLkn.....gv lgMdlsvsfgalsAfvysvy amlvs............... .qetyfeasstiltlvfgsk flElkarlfanekclaLesh eihsvivvengk........ ................qtek hpkdvaiGsvvwVpsGakia lDGvlln.nasvDaSlisGE fkPlelgvndpilgGyvNvg vpfsyqvsanfqnsrlsgll etlkksfleKpliessanqi adifskavlflafvsfllwq fglgg............... ................nfek almvcisVLvisCPCAfaLA tPialvigvfkn..plivfK ealfLEtlakvkkifiDKTG TLTqkevllkekiiy..... ..............eefdgr llksllkvreHlahsAIlks ldg........devslekie ffahGlkasyqne....... .................... .................... .....tllvGslkflgsmg. ..........vdipmkesan imvgfaknetlcalfileer lkanakevvqaLqnkGle.. ..leilsGDnessvkecAkk lGIsn..yhAhltPedKaqt issykg.............v caMVGDGnNDAlALAqAsvs lgf..eksalsksacDilLl ee......dLsllkkafdna qkvyqvvlqNivlsliYNai liPvAmlgy.......inPl iAs.lsmsaSsllVvlNslr Lkrs................ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O67432    Aquifex aeolicus                      CtrA2             .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............mrkafk VyGMsCvnCaraIEitlkrt eGVknvnVsfelgrveVefd edlis........eeeivkk IeelGYsverkkd....... .................... ...ydklflglgvlsslffl vgmfftfplk.......... .................... ....yelqfllssivqftaG wkfyrgayssLkk.....gi gsMdtLvalgttgAyvysvl syfnlin............. .stpffetnvflitfvrlGk fiEekakeravkglkeLvnL sfrkvkvlegek........ ................evek nvrevfkGekvvyrsGeqil lDGviikGeglvneaviTGE pvPilKkeGdeVysGsvlek Gyiitkvtktfessfintmk kLVeeslkeKpkiqrisDkv shyfvlfvvilsvitfltwf iktg................ ................einr avqfslaVLvvsCPCAfgiA vPlavsvgiykavkrGiLpK kgtifEvapkvdtviFDKTG TLTeGklkVkein....... .............vpekyfd vlysmEnySnHPvakAvrey lkp....yvkreaklegcee ilGvGvrcg........... .................... .................... .....efiaGkaelwgkn.. ...............sqngv irvgfgtkdkliGeiileDs vrkeakevvefLkgkGin.. ..villTGDtkenAqriAke lGIke..viAnvkPeeKlkv vkeLqe..........kgrk VcMVGDGvNDAPALAqsdlG iAva.eGtDlAklsgDvvih kl......sslpqvftlser vyr..kikeNffwAfaYNvt fiPiAagvlwskg.iylkPe fAg.llmalSsvsVvlNtlr Llkd................ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  53   Q59207    Bradyrhizobium japonicum              FixI              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ................mhvt rdfshyvrtagegikhidla VeGVhCagCmakIErglsai pdVtlarVnltdrrvalewk agtld........pgrfidr leelGYkaypfetesae... ................vaev aes.rfllrclgvaafatmn vmmlsipvwsgnvs...... ..............dmlpeq rdffhwlsalialpaaayaG qpffrsawraLsa.....kt tnMdvpisigvilAlgmsvv etihhae............. ..hayfdaaimlltfllvGr fldqnmrrrtravagnLaaL kaetAakfvgpde....... ................isqv pvaaispGDivllrPGerca vDGtvieGrseiDqSliTGE tlyVtaeqGtpVyaGsmNis GtlrvrvsaaseatllaeIa rLldnAlqarsrymrlaDra srlyaPvvhatalitilgwv iaga................ ................swhd aivtgvaVLiitCPCALgLA iPtvqtvasgamfksGvLln sgdaiErlaeadhviFDKTG TLTlpdleVmnaad...... .............ipadife lagrlalsShHPvaaAvaqa aga.......rspivgavee a.GqGvradvdga....... .................... .................... .....eirlGrpsfcgae.. ........alvgdgtrldpe asivafskgaekfilwvrqg lrpdaqaviaaLkarnig.. ..ieilsGDrepavkaaAha laIpe..wrAgvtPadKiar ieeLkr..........rgar VlMVGDGmNDAPsLAaAhvs mspi.saahlsqatADlvfl gr......pLapvaaaidsa rkalhlmrqNlwlAigYNvl avPvAisgv.......vtPl iAa.aamsgSsilVmlNslr arsdsreiv........... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O30733    Rhodobacter capsulatus                CcoI              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................mls lptahCavCitdVEremeaq pGVrsarVnltlkrvsVdae agvs.........aetlvea lakiGYeayeldpgmls... ................atet dkrgrdllmrigvagfammn imllsiavwsg......... ...............aeaat rdmfhwisaaialptvvfvG qpffasawggLkh.....gr vnMdvpislalilAssisif etmhhgh............. ..hayfdaavmlsffllvGr yldyrtravarsaaeeLaav evprAhllr.egv....... ................etiv pvadlkpGDsirVrPGgriP aDGevtsGtsetDrSllTGE tlPVyvgpGtmlsaGevNlt Gpltlrvtaagkdsslhrma dLVamAesaKtryttlaera araysPlvhalsfsafgywm watgg............... ................dlrf avnisaaVLiitCPCALgLA vPavitaasgklfrkGlLiK dgtaLErlaevdtvvFDKTG TLTmGapvlegldt...... .............ieeetls vaaalaqaSsHPlarAlvaa aear...d.irpvvlddlre vpGfGiegrlgal....... .................... .................... .....alrlGradwvgaa.. ................pcds TathlrlgaaepvtfrfsDh lrlgaaeavalLtaqGkr.. ..vlmvsGDvetavsalAgk laspn..ghsgalPaeKaal vadLmg..........qgrr VlMVGDGlNDtaALAaAhvs ispa.salDaArtasDivLl ga......dLapvgdalria gqarrrikdNfvisaaYNvv avPlAlvgl.......atPl aAa.lamstSsitVslNsmr Lk.................. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  54   P18398    Rhizobium meliloti                    FixI              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..................ms ccassaaimvaeggqaspas eelwlasrdlggglrqtels VpnayCgtCiatIEgalrak peVerarVnlssrrvsIvwk eevgg....rrtnpcdflha IaerGYqthlfspg...... ................eeeg ddllkqlilavavsgfaatn imllsvsvwsg......... ...............adaat rdlfhwisaliagpaliyaG rffyksawnairh.....gr tnMdvpialavslsygmslh etighge............. ..hawfdasvtllfflliGr tldhmmrgrartaisgLarL sprgAtvvhpdgs....... ................reyr avdeinpGDrliVaaGervP vDGrvlsGtsdlDrSvvnGE ssPtvvttGdtVqaGtlNlt GpltleataaardsfiaeIi gLmeaAeggraryrriaDra aryysPavhllalltfvgwm lveg................ ................dvrh amlvavaVLiitCPCALgLA vPvvqvvaagrlfqgGvmvK dgsamErlaeidtvllDKTG TLTiGkprlvnahe...... .............ispgrla taaaiavhSrHPiavAIqns aga.......aspiagdire ipGaGievktedg....... .................... .................... .....vyrlGsrdfavgg.. .............sgpdgrq seailsldfrelacfrfeDq prpasresieaLgrlGia.. ..tgilsGDrapvvaalAss lGIsn..wyAelsPreKvqv caaaae..........aghk alvVGDGiNDAPvLraAhvs mApa.taaDvgrqaADfvfm he......rLsavpfaiets rhagqlirqNfalAigYNvi avPiAilgy.......atPl vAa.vamssSslvVvfNalr Lkrslaagrgatpgtlihsg avts................ .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O33533    Rhizobium leguminosarum               FixI              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...................m scctmdaesvlalsttsfsa eevrlasqplgeglrqldls VsdvhCggCistIEralltl pfVktarVnltarrvtcvyq eeiea....ratdpskilge InsaGYrahlftps...... ................apes dktrnqlllaigvsgfaapn imllsvsvwsg......... ...............adaat rdmfhwisamiaapalvyaG rfffksawnaLrh.....gr tnMdvpisvtvslsyavslw etvhhge............. ..hawfdasvsllfflliGr tldhimrekaraaingLarL aprgAllinpdgs....... ................rryi aveeiaaGDeisiaaGervP vDGivvsGesdlDlSivTGE ssPVtvasdseVssGamNlt GslvlratriaknsllseIi gLmeaAeggraryrriaDra atlysPvvhllalvsflawg flgg................ ................dwkq amlvavaVLiitCPCALgLA vPvvqvvaagelfrkGimvK dgsaLErlaetdtvaFDKTG TLTmGssrlvrvda...... .............mdesaaa iarglaahSrHPlsrAlvrd tet.......apisfdrvte ipGgGlearngad....... .................... .................... .....iyrlGnaafacgt.. .........sfvprtadspf sevvlskngvdlarfffdDt lrpgaceaidrLdaaGle.. ..tlivsGDrqtvvdntAha lGIdr..algsltPkqKvee cqrLng..........egrr VlMVGDGiNDAPALAaAhvs mApa.tasDigrqaADlvff id......rLdavpeaiava rrsaslirqNfalAigYNvl avPiAiagl.......atPl iAa.vamstSsiiVvtNalr Lngfgkrpdmhirrgigrsa evkaa............... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  55   Q59370    Unknown                               Hra2              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............miayhi kkrrrhpmrdehehqhdheh hqhqdhtamsghnmhhehhe mamthddhdashtmrhdhaa mahhhmhmsddpgmahmdmt dmgrrfwwslalmvpiiiit plmgmtfpft.......... ..................lq fpgdtwvtailatilyivgt kpffvgakaeLka.....kr paMmsLvslsllvtfwysiy alvvntfwptah........ .vmdffwefatltvimllGh riEtaatmeagdatakLraL lpntAhvqhgdh........ ................fmdm pvsalkpdmvvqVlaGeafP aDGvilsGesqvDeSlmTGE srlidKkpGvsVvgGtiNgn Gtllvkvthvgaqsfigklq stlaasQsaKsrvetiaDqv asylfwvalliaglslmiwt p.thg............... .................lgf ainiavtVLviaCPhALgLA vPlviqrtkaiaAtqGiLiK nhkaLssanhltyvlmDKTG TLTtGqfkVmqvvtdn.... ............fdqkealg imaaldaqStHPlaqgIvsy akqqq....apvlsatdven maGyGiagmvndk....... .................... .................... .....hyllvserylkdhhi hytpl...........vadg TiyyllqhdhvvaavaqgDe ikattptfinyLkaqhli.. ..pilvTGDnaqvAqavAdq lGIte..ihAqvsPqeKial vkdyq...........kqgq VmMiGDGiNDAPALAqAdls vAiG.aGtqvAqaaADtvLi an......qLptiidflkLa kradrkqieNlwwgagYNii alPlAagalatfg.imlnPm iga.ilmslStviValNamt rka................. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O26849    Methanobacterium thermoautotrophicum  MTH755            .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ....mgrqkdhekgpgeime shghhekkgkmmdshghhee dyrrrfiicllmtipvillg ..elptgnvl.......... ..................fs fegseflvlilssaiflygG ypflrgslreLss.....rt pgMmtLiavaitvAytyslg vilgle.............. .gmvffvelvtlidvmllGh wiEmrsimsasgaverLagL lprrAhlvvdgk........ ................vedv dvstlkpGDivvVrsGervP sDGtvirGeshvneSllTGE srPikKvpGdgVigGsiNtg GsltvevervgeesfisqIi eLVgrAQegrtrtqvlaDka afwltsiallgglltfiaws wlgmd............... .................vff sleravtlmvtaCPhALgLA iPlviavstaisAgrGiLir nresfEnardpdvvvFDKTG TLTmGelgitdvisfdpe.. ............mdegeils yaaavEsgSsHPiargIvea vaev........lpvenfns leGrGvmghvngs....... .................... .................... .....vvkvlsygyteelgf sisdprvdelig.....qak TtvfvivddelrGcialaDm irpeareavgiLrsrGvr.. ..clmlTGDssavAgwvAse vGIdd..ymAeliPieKyde irkLqe..........eglr VvMVGDGvNDAPALvqAdiG vAiG.aGtDvAiesADvvLv rs......npldvvdlmdLa aaTyskmkeNliwAtgYNvi alPlAagvlygqg.iilsPa mga.ilmslStviValNart fsfsgqsgr........... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O30085    Archaeoglobus fulgidus                AF0152            .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ....mhehdshgeaahsnse dmqmihqhhehhgheeehsa hhekmkhsadhgdhhrmmme dfkkrfyvstlltipilils paiqtflgfr.......... ..................ve fagslyilfllssavyfygG ypflkgifdeLrr.....rq pgMmtLiavaisvAyfyssa vvfglk.............. .gkfffwelatlidimllGh yiEmrsvlgasraleeLvki mpseAhllkdge........ ................ivev kvenlkpGDkvlVkPGekiP vDGivveGesfvneamlTGE skPVaKkpGdtVigGaiNge Gslvvevektgkdtylnqvi eLVrqAQesKsrtqdlanra allltvialtvgsvtlaiwl ayiad............... .................faf aieravtVmvitCPhALgLA iPlvvavstslaAksGlLir drqafErakdlqaviFDKTG TLTeGrfgVtdivgfnhs.. ............ede..llq iaaslEarSeHPiaaAIvee aekrg....fglteveefra ipGkGvegivngr....... .................... .................... .....rymvvspgyirelgi ktdesveklkq......qgk TvvfilkngevsGvialaDr irpesreaiskLkaiGik.. ..cmmlTGDnrfvAkwvAee lGldd..yfAevlPheKaek vkevq...........qkyv taMVGDGvNDAPALAqAdvG iAiG.aGtDvAvetADivLv rn......dprdvaaiveLs rkTyskmkqNllwAtgYNaf aiPlAagvlysag.illsPa vga.ilmslStviVaiNarl Lr.................. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
   -   O67203    Aquifex aeolicus                      CtrA3             .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ..............mhehhd khkhelkrksekhehahhae iikrkalittiltvpvvvls psiqeligik.......... ..................vs fpysnwvilllstavfiygG tfflkgmleeLkk.....kn pgMmtLvglaisvAyiysvy tfffg............... .gkeffwelttlivvmlwGh yvEmksvlgagraleeLvkL ipskAhlvtqkg........ ................lidv pveklkkGDlvlVrPGekiP tDGtvveGnthvDeSmlTGE srPVpKkpGdkVigGsvNle Gsikvrvektgeetylkqvi kLVkeAQesKtklqslaDra afyltviavslgsisllfww yylgd............... .................lnf averavtVmvtaCPhALgLA iPlvvsistsysArnGiLvr nrlaLEkakdidvvvFDKTG TLTeGklgVtevitkdie.. ............ege..flk fvasvEnhSeHviarAIvsy akek........eevknfka fpGkGvcgevsgr....... .................... .................... .....nvcvGtleflkeinv kldeelver..arslqsegk TvvfasmdgklaGiialaDr ikeesyeavrsLkelGkk.. ..vvmiTGDseevAkyvAke lemde..yfArvlPheKaqk ikeLqd..........rgys VaMVGDGvNDAPALiqAdvG iAiG.sGtDiAiesADviLv ks......dprdvvkvikLs qvTvskmlqNlfwAvgYNvi tlPlAtglgypwg.fvlkPa vga.ifmsaStviValNsml mkkelr.............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  56   P05425    Enterococcus hirae                    CopB              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ...................m nngidpenetnkkgaigknp eekitveqtntknnlqehgk menmdqhhthghmerhqqmd hghmsgmdhshmdhedmsgm nhshmghenmsgmdhsmhmg nfkqkfwlslilaipiilfs pmmgmsfpfq.......... ..................vt fpgsnwvvlvlatilfiygG qpflsgakmeLkq.....ks paMmtLiamgitvAyvysvy sfianlinphth........ .vmdffwelatlivimllGh wiEmnavsnasdalqkLaeL lpesvkrlkkdgt....... ................eetv slkevheGDrliVraGdkmP tDGtidkGhtivDeSavTGE skgVkKqvGdsVigGsiNgd Gtieitvtgtgengylakvm emVrkAQgeKskleflsDkv akwlfyvalvvgiiafiawl f.lan............... .................lpd alermvtVfiiaCPhALgLA iPlvvarstsiaAknGlLlK nrnamEqandldvimlDKTG TLTqGkftVtgieildea.. ............yqeeeilk yigalEahanHPlaigImny lkekk....itpyqaqeqkn laGvGleatvedk....... .................... .................... .....dvkiinekeakrlgl kidperlknyea.....qgn TvsflvvsdklvavialgDv ikpeakefiqaikeknii.. ..pvmlTGDnpkaAqavAey lGIne..yyggllPddKeai vqryld..........qgkk ViMVGDGiNDAPsLArAtiG mAiG.aGtDiAidsADvvLt ns......dpkdilhfleLa keTrrkmiqNlwwgagYNii aiPlAagilapig.lilsPa vga.vlmslStvvValNalt Lk.................. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
  57   Q59369    Unknown                               Hra1              .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .......mrnnkqhsshshh nhgdmehskhdhnEmehsqm dhsamghcamgghahhhhgd mdhskhdhnemkhsqmdhsk mdysemdhgamgghahhhhg sfkdiflkslplgiaillit plmgiqlpfq.......... ..................ii fpyadvvaavlatilyifgG kpflmgakdefns.....kv pgMmsLitlgitvsyaysvy avaaryvtgep......... .vmdfffefttlilimllGh wiEmkalgeagnaqkaLaeL vpkdAhvvledds....... ................ietr pvadlqvGDlirVqaGenvP aDGtiqrGesrvnealvTGE skPieKnpGdeVigGstNgd Gvlyveikqtgdksfisqvq tLisqAQsqpsraenlaqkv agwlfyiaviaalialviwm v.iad............... .................vpt aviftvttLviaCPhALgLA iPlvtarstslgAsrGlLvK drdaLElttnadvmvlDKTG TLTtGefkVldvelfndk.. ............ytkdeiva llsgiEggSsHPiaqsIisy aeqqg....irpvsfdsidv msGaGvegqangh....... .................... .................... .....ryqlisqk.aygrnl dmdip............kga TisvlvendeaiGavalgDe lkptskdliqaLkknkiq.. ..pimaTGdnekaAqgaAei lGId...ylanqsPqdKyel vekLka..........egkk ViMVGDGvNDAPsLAlAdvG iAiG.aGtqvAldsADiiLt qy......spgdiasfieLa qkTtrkmkeNlvwgagYNfi aiPiAagilapig.itlsPa vAa.vlmslStviVaiNamt Lklepk.............. .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
       Q58378    Methanococcus jannaschii              MJ0968            .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .........mkvaivFDsaG TLvkimrvikdlk....... ...........knkficnsqtv divdkkkgr                                   ycnppinregi..... .................... .................... ...fkdrktkvkelqepl.. .....nilk.rye..vetgy gsa                                                                    maeahqelKrdl irnLkk..........egyf tiMVGDGaNDvPamiesdla vvtl.qngnvsrra
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         alviikedplk vvdk...e.npeklisdllk eveiGis                                                                                                   liidtyageveytiatagc lfkevketikqlkdlGvk.. ..vfiasGDrkgfikrlAei tGvder.yi                                                                 letADikiy n........ikeivdickkv ingeikgrmqikecs..... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... .................... ........... 
Identical in 49 of the 70 sequences                                      -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -----C-------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------G ----------L--------- --M--L-------A------ -------------------- ------------------G- --E-------------L--L ----A--------------- -------------------- -------GD---V-PG---P -DG----G----D-S--TGE --PV-K--G--V--G--N-- G-----------------I- -LV--AQ--K-------D-- -----P-------------- -------------------- -------------------- -------VL---CPCAL-LA -P----------A--G-L-K ----LE---------FDKTG TLT-G---V----------- -------------------- -----E--S-HP---AI--- -------------------- --G-G--------------- -------------------- -------------------- ---------G---------- -------------------- T-----------G-----D- -----------L---G---- ------TGD----A---A-- -GI------A---P--K--- ---L---------------- V-MVGDG-NDAPALA-A--G -A-G--G-D-A---AD--L- ---------L--------L- --T------N---A--YN-- --P-A-------------P- -A-------S---V--N--- L------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- ----------- 
Identical in all 70 sequences                                            -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -D----------------GE -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------P------ -------------------- ----------------DKTG T-T----------------- -------------------- ----------H--------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------GD----------- -------------P--K--- -------------------- ----G-G-ND---------- -------------------- -------------------- ---------N---------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- ----------- 
Identical in 15 of 21 probable cadmium and zinc transporting ATPases     -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------G -------------------- -----LM--A--GA---G-- -------------------- -------E-------F---- -LE-----R-------L--- -P--A--------------- -------------------V -------GD---V-PG---- -DG----G---------TGE S-PV-------V-AG--N-- G-----------------I- -LV--A---------F---F ---Y---------------P -------------------- -------------------- --Y--L--L----PCAL--S -P------I--AA--G-L-K G---LE-L------AFDKTG TLT-G---V----------- -------------------- -----E--S-HP-A-AI--- -------------------- --G-G------G-------- -------------------- -------------------- ---------G---------- ------------------G- T-----------G-I---D- -R---------L---G---- ----MLTGD----A------ -G---------L-P-DK--- ---L---------------- --MVGDG-NDAPALA-A--G IAMG--G-D-A-ETAD--L- -D-------L---------- R--------N---------- -------G----------L- -AV-----G-T-LV--N--R L------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- ----------- 
Identical in all 21 probable cadmium and zinc transporting ATPases       -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- ----------------L--- ----A--------------- -------------------- -------------------- -D----------------GE --P----------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------PC----- ---------------G-L-K ----------------DKTG T-T----------------- -------------------- ----------HP-------- -------------------- --G----------------- -------------------- -------------------- -------------------- -------------------- ------------------D- -------------------- -----L-GD----------- -G-----------P--K--- -------------------- ----G-G-ND---------- -------------------- -------------------- ---------N---------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -----------  
Identical in 35 of 49 probable copper transporting ATPases               -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -----C--C----------- -------V------------ -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------G --F---A---L--------- --M--L-------A---S-- -------------------- -----F------------G- --E---------A---L--L ----A--------------- -------------------- -------GD---V-PG---P -DG----G----DES--TGE --PV-K--G--V--G--N-- G---------G----L--I- --V--AQ--K------AD-- ---F-P------------W- -------------------- -------------------- A------VL-IACPCALGLA TP----V-----A--G-L-K ----LE---------FDKTG TLT-G---V----------- ------------------L- -----E--S-HP---A---- -------------------- --G-G--------------- -------------------- -------------------- ---------G---------- -------------------- ------------------D- -K---------L---G---- ------TGDN---A---A-- -GI------A---P--K--- ---L-------------G-- V-MVGDG-ND-PALA-A--G -A----G-D-A---AD--L- ---------L--V-----L- --T---I--N---A--YN-- -IP-AAG---------L-P- -A---AM--SS--V----L- L------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -----------  
Identical in all 49 probable copper transporting ATPases                 -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- --M----------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -DG---------------GE -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- ------------CP------ -------------------- ----------------DKTG T-T----------------- -------------------- ----------H--------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------GD----------- -------------P--K--- -------------------- ----GDG-ND---L------ -------------------- -------------------- ---------N------YN-- ----A-------------P- -------------V------ -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -------------------- -----------  
Conserved segments in all P-type ATPases                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       aaaaaaaaaaaaaaaaaaaa aaaaa      bbbbbbbbb bbbbbbbbbbb cccccccc cccccccccccccccccc                                                                                        ddddddddddddddddddd ddddd          eeeee eeeeeeeeeeeeeeeeeeee eeeeeeeeeee                                                                                                                                                                                     fffffffffffffffff ffffffffffffffffff     ffffffffffffffffff ffff   ggggggggggggg gggggg          gggg gggggggggggggggggggg ggg   hhhhhhhhhhhhhh hh      hhhhhhhhhhhh hhh                  
Transmembrane helices                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        111111111111111 1111111                                         22222222222222 222222            33 3333333333333333333                             44444444444444 4444444                                                                                                                                                               5 55555555555555555555 55                                         666666666666666666                                                                                                                                                                                                                                                                                                                                                                                                                        7777777777777 7777777            8 8888888888888888888                                                                 
Heavy metal associated domains                                                ++++++++v+GM+C+ +C+++iE+++++++Gv++++ V++++++++v++++++++++ +++++i+++Gf++++++      ++++++++v+GM+C++C+ ++iE+++++++Gv++++V++ ++++++v+++++++++++++ ++i+++Gf++++++               ++++++++v+GM +C++C+++iE+++++++Gv+ +++V++++++++v+++++++ ++++++++i+++Gf++++++                                             ++++++++v+GM+C++C+ ++iE+++++++Gv++++V++ ++++++v+++++++++++++ ++i+++Gf++++++                                ++++++++v+GM+C++ C+++iE+++++++Gv++++V ++++++++v+++++++++++ ++++i+++Gf++++++                                                            +++++++ +v+GM+C++C+++iE+++++ ++Gv++++V++++++++v++ ++++++++++++++i+++Gf ++++++      ++++++++ v+GM+C++C+++iE++++++ +Gv++++V++++++++v+++ ++++++++++++++++++++ i+++Gf++++++
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Last update 10-4-2002 by Kristian B. Axelsen.