Alignment of beta subunits of P2C ATPases (Na+/K+ + H+/K+)
The alignment was performed on The Danish Biotechnological Database with the programme CLUSTALW with default settings. The alignment was refined by hand. The grouping of P-type ATPases and the nomenclature is adopted from the work described in
Axelsen, K.B. & Palmgren, M.G. (1998) J. Mol. Evol. 46: 84-101.
The position of the transmembrane helix is adopted from the annotation of the proteins in SwissProt. It might, therefore, be slightly different in the proteins in vivo.
The positions of the disulfide bridges are likewise indicated based on the annotation found in SwissProt.
The glycosylated amino acids are marked with magenta colouration where they have experimentally determined, that is, in the ATP1B1 proteins of sheep (P05028) and dog (P06583)(Treuheit, M.J. et al. (1993) J. Biol. Chem. 268: 13914-13919) and in the ATP4B protein of rabbit (P18597)(Tyagarajan, K. et al. (1997) Biochemistry 36: 10200-10212).
Amino acids in the alignment shown in CAPITALS are at least present in 88% (35 of 40) of the beta subunits.
Accession Organism Name
number 1 100 101 200 201 300 301 391
Q24046 Drosophila melanogaster NRV1/Beta-1 .............msknngk gakgefefpqpakkqtfsem iyNpqegtffGRTgksWsql llfYtiFYivlaalFticmq gllsTisdt.ePkwklqdsl igtnPGlgfrPlseqte.rg sviafdgk.kpaesdywiel iddFLrdYnhtegrd..... mkhCgfgqvlept....... ....dvCvvntdlfgg.... ..Cskann...yGyktnqPC iflKlNkifg......wiPe vydkeekdmpddlkkvinet kteer.......hevwvsCf ghlgkd....kenfqniryf psq......gfpsyYyPfln ...qpgYlsPlvAvqfn..s ppkgqmldveCrawak.niq ysgsardrkGsvtfqilld. ...........
Q9V3Q7 Drosophila melanogaster Jybeta2 mpedvmvpagdyklvkqirr nqetrr.....kkdlpwskr ifdidehklfGRTalgWmrI tgfYlvlYalivcivafwlg ifmlaiidpnkPrwlkg... ...pPGlsmvPnqn....rs vlayfthi..msevnpiadr iddFLnklndnaidffadfn qdttwgyatekp.....tvf iklnkvigyvpetydtpddl pkeapaslqdtvGklgntPk iwitcevtngpkpemvfyPg pyfeasenmrgvtrvvaiqm nkmpen......aktffsCk vwarnipidddyqgmgiikf alsmrtdddgnpdferPstr kapreidleseelvpep..p spnrpesmlgglelpppped ekdaldamgndakkeemtep psl........
Q24048 Drosophila melanogaster NRV2/Beta-2 .mptitedcidgfqqyy..s rpperp......kkkslkqm vydsednsyfGRsmdsWakI gifYvaFYgvlaalvaicmw affqTldpr.iPkwtldrsl igtnPGlgfrPlppvdnves tliwykgt.qhenykhwtds lddFLavYkvpgltpgrgqn iynCdynqp........... ppkaqvCdvdiktwsp.... ..Ctkenn...ysyhksaPC iflKlNkiyg......wiPe yy.nrsndlpanmpaslkty iaevektqpeklntiwvsCe genpad....qenigavnyl pir......gfpgyfyPYq. ..nsegYlsPlvAvhfq..r pkrgiiinveCrawar.nii rdr..keriGsvhyellid. ...........
Q9V443 Drosophila melanogaster JYbeta1 ....madkkig...eyy..a ppvkmg......kwegfkkf lwNsetsqclGRTgssWakI llfYiiFYaaltgfFaaift vfyqTldne.kPkwmldngl igsnPGlgfrPmppeanves tlvwyess.kkdnykywvde tsrFLksYqdlekq.....n qvnCsfehp........... pqddkvCgidfssfsp.... ..Ctadnn...fGyhvarPC iflKlNkiyn......wiPe iy.ndsktlpdhmpeelkqh ikekqslrpnetnvvwvsCe genpad....venikardyy prm......gfpryYfPfk. ..niqgYipPivAvqft... vetgvlinieCkawar.nin hdr..sdrrGsvhfelmvd. ...........
P25169 Artemia salina BETA ....madkkpd..eqfv..g sgpket......kwqsfkgf vwNsetsqfmGRTagsWakI tifYviFYtllagfFagmlm ifyqTldfk.iPkwqnkdsl iganPGlgfrPmppeaqvds tliqfkhg.ikgdwqywvhs lteFLepYetltss...gqe ftnCdfdkp........... pqegkaCnFnvellgdh... ..Ctkenn...fGyelGkPC vliKltdfg.......wrPe vy.nssaevpedmpadlksy ikdietgnkthmnmvwlsCe getand....kekigtityt pfr......gfpayYyPYl. ..nvpgYltPvvAlqfg..s lqngqavnveCkawan.nis rdr..qrrlGsvhfeirmd. ...........
Q93235 Caenorhabditis elegans C17E4.9 .....mekkvde.natl..m ngvettgparddvpetfref lyNkkngtvmGRTgksWfqI ivfYiiFYaflaafwltclt ifmkTldpk.vPrfygkgti igvnPGvgyqPwlker.pds tlikynlr.dqksykayleq mktyLtkYdsnatetre... ...Cgagdsnddlek..... npdalpCrFdlsvfdkg... ..Cseksd...fGyksGkPC viislNRlig......wrPt dy.qe.nsvpeevkdrykag s.............iainCr gatnvd....qehigkvtym psn......gidgrYyPYv. ..ftkgYqqPiamvkfd..t iprnklviveCrayal.nie hdi..ssrlGmvyfevmved k.pveekkel.
Q9XUY5 Caenorhabditis elegans F55F3.3 ..mtnggrngee.nknl..m ngeaka......epetfaqf lyNkdkgtvlGRTgtsWcqI tvfYiiFYiflsafFigcls iflrTldpk.vPrfygkgti igvnPGvgyqPwlken.pds tlikfnlq.dskswepyvkq ldnyLskYk.ntnetrd... ...Cgasdnndalet..... dtdtfpCrFdlglfekan.. ..Cgakdq...yGyksGkPC vavslNRlig......wrPv ny.dd.gsvpeeikgrykpg s.............itinCe gatsfd....kehlgkvkyi pet......gidgrYyPYv. ..fvpsYqqPiamvkfd..t iprnklviveCrayas.nie hdi..strlGmvyfelfved kkpvaapaa..
P51164 Homo sapiens ATP4B .............maal..q ekktcg.....qrmeefqry cwNpdtgqmlGRTlsrWvwI slyYvaFYvvmtglFalcly vlmqTvdpy.tPdyqdq... lr.sPGvtlrPdvyge..kg leivynvs.dnrtwadltqt lhaFLagYspaaqed..... sinCtseqyffqesfr..ap nhtkfsCkFtadmlqn.... ..Csglad.pnfGfeeGkPC fiiKmNRivk......flPs ...ngsa............. ..............prvdCa fldqpre...lgqplqvkyy ppn.....gtfslhYfPYyg kkaqphYsnPlvAakll..n iprnaevaivCkvmae.hvt fnnphdpyeGkvefklkiek ...........
P18434 Sus scrofa ATP4B .............maal..q ekkscs.....qrmeefqry cwNpdtgqmlGRTlsrWvwI slyYvaFYvvmsgiFalciy vlmrTidpy.tPdyqdq... lk.sPGvtlrPdvyge..kg ldisynvs.dsttwaglaht lhrFLagYspaaqeg..... sinCtsekyffqesfl..ap nhtkfsCkFtadmlqn.... ..Csgrpd.ptfGfaeGkPC fiiKmNRivk......flPg ...nsta............. ..............prvdCa fldqpr....dgpplqveyf pan.....gtyslhYfPYyg kkaqphYsnPlvAakll..n vprnrdvvivCkilae.hvs fdnphdpyeGkvefklkiqk ...........
P50992 Mus musculus ATP4B .............maal..q ekkscs.....qrmaefrhy cwNpdtgqmlGRTparWvwI slyYagFYvvmtglFalciy vlmqTidpy.tPdyqdq... lk.sPGvtlrPdvyge..rg lkisynvs.ensswagltht lhsFLagYtpasqqd..... sinCtsekyffqesfa..ap nhtkfsCkFtadmlqn.... ..Csglad.psfGfeeGkPC fiiKmNRivk......flPs ...nnta............. ..............prvdCt fqddpqkprkdteplqveyy ppn.....gtfslhYfPYyg kkaqphYsnPlvAakll..n vpknmqvsivCkilad.hvt fnnphdpyeGkvefkltiqk ...........
P18598 Rattus norvegicus ATP4B .............maal..q ekkscs.....qrmaefrqy cwNpdtgqmlGRTparWvwI slyYaaFYvvmtglFalciy vlmqTidpy.tPdyqdq... lk.sPGvtlrPdvyge..rg lqisynis.ensswagltht lhsFLagYtpasqqd..... sinCssekyffqetfs..ap nhtkfsCkFtadmlqn.... ..Csglvd.psfGfeeGkPC fiiKmNRivk......flPs ...nnta............. ..............prvdCt fqddpqkprkdieplqvqyy ppn.....gtfslhYfPYyg kkaqphYsnPlvAakfl..n vpkntqvlivCkimad.hvt fdnphdpyeGkvefkltiqk ...........
P18597 Oryctolagus cuniculus ATP4B .............maal..q ekkscs.....qrmeefrhy cwNpdtgqmlGRTlsrWvwI slyYvaFYvvmtglFalciy vlmqTidpy.tPdyqdq... lk.sPGvtlrPdvyge..kg leihynis.dnrtwtsltht lrsFLagYspaaqvd..... ninCtsktyffqesfg..ap nhtkfsCkFtadmlen.... ..Csgltd.psfGfkeGkPC fiiKmNRivr......flPs ...nstp............. ..............prvdCt fldmp...hqaltplqveyy ppn.....gtfslhYfPYyg kkaqphYsnPlvAakll..n vptntevvvlCkilad.hvt fdnphdpyeGkvefklkiqk ...........
P33704 Canis familiaris ATP4B .............maal..q ekkscs.....qrmeefqry cwNpdtgqmlGRTlsrWvwI slyYvaFYvvmtgiFalciy tlmcTldpy.tPdyqdq... lk.sPGvtlrPdvyge..kg ldisynvs.dnrtwvdlvni lhnFLegYsptsqed..... ninCtsekyffqdvfg..ap nhtkfsCkFmadmlqn.... ..Csgltd.pnfGfaeGkPC fiiKmNRivn......flPs ...nsta............. ..............pradCt fldqhk....ddrplqveyy ppn.....gtfslrYfPYyg kkaqphYsnPlvAakll..n vprntevlivCkilad.yvt fdnphdpyeGkvefkltiqq ...........
Q07420 Gallus gallus Beta .............matl..n ekktcs.....ermenfrrf vwNpetklfmGRTlinWvwI slyYlaFYvvmtgiFalsiy slmrTvnpy.ePdyqdq... lk.sPGvtlrPdvygh..rg lqiyynas.dnktweglvtm lqtFLtaYspaaqhl..... ninCtsntyfiqntfd..gp nntklsCkFtsdmlqn.... ..Csgitd.ptfGfpeGkPC fivKmNRiik......fyPg ...ngta............. ..............prvdCs yvgde......srpleveyy pvn.....gtfnlhYfPYyg kkaqptYsnPlvAvkfl..n itknvevqivCkiiga.git fdnvhdpyeGkvefklkied gaardtskkhv
O57527 Xenopus laevis Beta .............matf..n ekktcs.....qrmenfgrf vwNpdtsefmGRTfakWvyI slyYaaFYvimvgiFalsiy slmqTlspy.vPdyqde... lk.sPGvtlrPdpygd..ev ielfynma.dnktylplvts lceFLpvYnksvqek....m nanCsdhtriscahq..... nentksCqFttdmlgn.... ..Cswehd.htfGyksGkPC lfiKmNRiin......fvPg ...nkta............. ..............plvnCs aenge........lgdvqyy pgnd..tygtiglqYfPYcg kkmqpnYtnPlvAvkll..n ptlnkelsvvCkvsgh.git sdnphdpyeGkvsfklkien kplsssan...
P14231 Mus musculus ATP1B2 .............mviq..k ekkscg.....qvveewkef vwNprthqfmGRTgtsWafI llfYlvFYgfltamFsltmw vmlqTvsdh.tPkyqdr... la.tPGlmirPkten..... ldvivnis.dteswgqhvqk lnkFLepYndsiqaq....k ndvCrpgryyeqpdng..vl nypkraCqFnrtqlgd.... ..CsgigdpthyGystGqPC vfiKmNRvin......fyag ..anqs.............. ..............mnvtCv gkrded....aenlghfvmf pan.....gsidlmYfPYyg kkfhvnYtqPlvAvkfl..n vtpnvevnveCrinaa.nia tdderdkfaGrvafklrink t..........
P13638 Rattus norvegicus ATP1B2 .............mviq..k ekkscg.....qvveewkef vwNprthqfmGRTgtsWafI llfYlvFYgfltamFtltmw vmlqTvsdh.tPkyqdr... la.tPGlmirPkten..... ldvivnis.dteswdqhvqk lnkFLepYndsiqaq....k ndvCrpgryyeqpdng..vl nypkraCqFnrtqlgn.... ..CsgigdpthyGystGqPC vfiKmNRvin......fyag ..anqs.............. ..............mnvtCv gkkded....aenlghfimf pan.....gnidlmYfPYyg kkfhvnYtqPlvAvkfl..n vtpnvevnveCrinaa.nia tdderdkfaarvafklrink a..........
Q28030 Bos taurus ATP1B2 .............mviq..k ekkscg.....qvveewkef vwNprthqfmGRTgtsWafI llfYlvFYgfltamFtltmw vmlqTvsdh.tPkyqdr... la.tPGlmirPkten..... ldvivnvs.dteswdqhvqk lnkFLepYndsiqaq....k ndvCrpgryyeqpdng..vl nypkraCqFnrtqlgd.... ..CsgigdpthyGystGqPC vfiKmNRvis......fyag ..anqs.............. ..............mnvtCv gkrded....aenlgnfvmf pan.....gnidliYfPYyg kkfhvnYtqPlvAvkfl..n vtpnvevnveCrinaa.nia tdderdkfaprvafklrink t..........
P14415 Homo sapiens ATP1B2 .............mviq..k ekkscg.....qvveewkef vwNprthqfmGRTgtsWafI llfYlvFYgfptamFtltmw vmlqTvsdh.tPkyqdr... la.tPGlmirPkten..... ldvivnvs.dteswdqhvqk lnkFLepYndsmqaq....k ndvCrpgryyeqpdng..vl nypklaCqFnrtqlgn.... ..CsgigdsthyGystGqPC vfiKmNRvin......fyag ..anqs.............. ..............mnvtCa gkrded....aenlgnfvmf pan.....gnidlmYfPYyg kkfhvnYtqPlvAvkfl..n vtpnvevnveCrinaa.nia tdderdkfaGrvafklrink t..........
P43002 Bufo marinus Beta-2 .............maal..t qkktcs.....qmmeewkef mwNprtrefmGRTgssWalI llfYvvFYafltavFslslw vmlqTidey.tPkyadr... la.nPGlmirPkmdt..... tevvystngmngtwqayvdn lnslLkdYnktvqme....r gvnCtpgvynmqedtgd.vr nnpkkaCwFfrdvlgd.... ..Csgvsd.ttyGyqdGkPC vliKmNRvin......flPv pikelsnts........... ..............itikCt aqnnd......dllgsiqyf psvnnqslgaidlmYfPYyg nraqqnYtqPfvAvkfl..n atkgvdhmveCrvnaa.nin nqdprdlyqGrviftmkidr l..........
Q60489 Cavia porcellus ATP1B3 .............mtk...s ekksln.....eslaqwklf lyNpttreflGRTaksWglI llfYlvFYgflaalFtftmw amlqTlnde.iPkyrdq... ip.sPGlmvfPkpv....ta leytfsvs.dpssyegyikd lkkFLksYsldeqkn..... lnkCtdgvlfeqt....... gpvyaaCqFpdsllea.... ..Csgtddp.dfGysqGqPC vlvKmNRiig......lkPe ..gs................ ..............pridCi skden........tamvsty pnq.....gvidlkYfPYyg kklhvgYlqPlvAvqvsfgs nstkkevtveCkiegsknlr neddrdkflGrvafkitara ...........
P54709 Homo sapiens ATP1B3 .............mtk...n ekksln.....qslaewklf iyNpttgeflGRTaksWglI llfYlvFYgflaalFsftmw vmlqTlnde.vPkyrdq... ip.sPGlmvfPkpv....ta leytfsrs.dptsyagyied lkkFLkpYtleeqkn..... ltvCpdgalfeqk....... gpvyvaCqFpisllqa.... ..Csgmndp.dfGysqGnPC ilvKmNRiig......lkPe ..gv................ ..............pridCv skned........ipnvavy phn.....gmidlkYfPYyg kklhvgYlqPlvAvqvsfap nntgkevtveCkidgsanlk sqddrdkflGrvmfkitara ...........
P97370 Mus musculus ATP1B3 .............mtk...t ekksfh.....qslaewklf iyNpssgeflGRTsksWglI llfYlvFYgflaalFtftmw amlqTlnde.vPkyrdq... ip.sPGlmvfPkpq....ta leytfsms.epqtykklved lesFLkpYsveeqkn..... ltsCpdgapfiqh....... gpdyraCqFpvsllee.... ..Csgvtda.nfGyskGqPC ilvKmNRiid......liPd ..gy................ ..............pqisCl pkee.........natiaty pef.....gvldlkYfPYyg kkrhvgYrqPlvAvqvkfds glnkkevtveChiagtrnlk nknerdkflGrvsfkvtara ...........
Q63377 Rattus norvegicus ATP1B3 .............mtk...t ekksfh.....qslaewklf iyNptsgeflGRTsksWglI llfYlvFYgflaalFtftmw vmlqTlnde.vPkyrdq... ip.sPGlmvfPkpp....ta ldytysms.dphtykkfved lknFLkpYsveeqkn..... ltdCpggalfhqe....... gpdysaCqFpvsllqe.... ..Csgvnds.nfGyskGqPC vlvKmNRiie......lvPd ..ga................ ..............pyitCi tkeen........ianivty pdd.....glidlkYfPYyg kkrhvgYrqPlvAvqvifga datkkevtieCqidgtrnlk nknerdkflGrvsfkviaha ...........
P33879 Gallus gallus ATP1B2 .............msk...e tkkpfr.....qsvaewrqf vyNpnsgeflGRTaksWglI llfYlvFYgflaalFtftmw vmlqTlsnd.iPkyrdr... is.sPGlmisPkpd....ta lefyfnks.daqsyaeyvst lrkFLetYddskqsq..... ninCtpgkvfdqnd...... vavkkaCrFnlselgq.... ..Csgkedk.tfGyskGtPC vlvKmNRiig......lkPe ..ge................ ..............pyiqCt skepg........aveinyf psg.....glidlmYfPYyg ktlhahYlqPlvAvqlains nstneeiaieCkilgspnlk neddrdkflGriafkvemte ...........
P30716 Bufo marinus Beta-3 .............mak...e enksge.....qsssewkqf iyNpssgeilGRTassWalI llfYlvFYgflaglFtltmw vmlqTldds.vPkyrdr... vs.fPGlmisPk.s....ag leisfsks..dkshmksilk ffthfy.hhtmtpyk..... lqmCsarkaitteqeg.... veekksCqFnrsslgp.... ..CaglegneyfGyndGsPC vlvKmNRiig......lkPd ..gn................ ..............phinCt skae.........nislqyy pey.....gkidlmYyPYyg kkthvnYvqPlvAvkitpsn stgtseivleCklygspnlk nnddrdkflGrvnfkleikd ...........
P21188 Xenopus laevis ATP1B3 .............mak...e enkgse.....qsgsdwkqf iyNpqkgefmGRTassWalI llfYlvFYgflaglFtltmw vmlqTldds.vPkyrdr... vs.sPGlmisPk.s....ag leikfsrs.ktqsymeyvqt lntFLapYndsiqak..... nefCppglyfdqdee..... .vekktCqFnrtslgi.... ..Csgiedp.mfGygeGkPC vivKiNRiig......lkPe ..gn................ ..............pkinCt skte.........dvnlqyf pdn.....gkidlmYfPYyg kkthvnYvqPvvAvkispsn .ftseeiaveCkihgsrnlk nederdkflGrvtfkvkite ...........
Q90266 Brachydanio rerio NAKATPB .............mskk..s enqrra.....ksreqlerr dlhprtgelfGRTarnWglI llfYlvFYgflaamFvftlw vmlqTlndd.tPkyrdr... va.sPGlvirPn.s...... lniefnrs.dpleygqyvqh lesFLhqYndseqak..... ndlCyggtvpeqdg...... eslkkvCqFkrsllys.... ..Csgmedt.tfGyakGqPC vivKmNRiig......lkPs ..gd................ ..............pyinCt sksvk........plqmtsi spm.....rtidrmYfPYyg kkthkgYvqPlvAvklllkk edynseliveCkvegs.nlk nnderdkflGrvtfrvlvte ...........
P05027 Sus scrofa ATP1B1 .............marg..k ake..........egswkkf iwNsekkeflGRTggsWfkI llfYviFYgclagiFigtiq vmllTisef.kPtyqdr... va.pPGltqiPqsq.....k teisfrpn.dpqsyesyvvs ivrFLekYkdlaqkd..dmi fedCgnvpselkergeynne rgerkvCrFrlewlgn.... ..Csglnd.etyGykdGkPC viiKlNRvlg......fkPk ppknesletyp.vmkynpyv ..............lpvhCt gkrded....kekvgtmeyf glgg...ypgfplqYyPYyg kllqpkYlqPlmAvqft..n ltmdteirieCkayge.nig yse.kdrfqGrfdvkievks ...........
P05028 Ovis aries ATP1B1 .............marg..k ake..........egswkkf iwNsekkeflGRTggsWfkI llfYviFYgclagiFigtiq vmllTisef.kPtyqdr... va.pPGltqiPqiq.....k teiafrpn.dpksymtyvdn idnFLkkYrdsaqkd..dmi fedCgnvpselkdrgefnne qgerkvCrFklewlgn.... ..Csgind.etyGykeGkPC viiKlNRvlg......fkPk ppknesletyp.vmkynpyv ..............lpvqCt gkrded....kekvgsieyf glgg...ypgfplqYyPYyg kllqpkYlqPllAvqft..n ltmdteirieCkayge.nig yse.kdrfqGrfdvkievks ...........
P06583 Canis familiaris Beta-1 .............marg..k ake..........egswkkf iwNsekkeflGRTggsWfkI llfYviFYgclagiFigtiq vmllTisef.kPtyqdr... va.pPGltqiPqiq.....k teisfrpn.dpksyeeyvrn ivrFLekYkdsaqkd..emi fedCgnmpseikergefnne rgerkvCrFklewlgn.... ..Csgind.etyGyrdGkPC vliKlNRvlg......fkPk ppknesleayp.vmkyspyv ..............lpvqCt gkrded....kdrignveyf glgg...ypgfplqYyPYyg kllqpkYlqPllAvqft..n ltmdteirieCkayge.nig yse.kdrfqGrfdvkievks ...........
P14094 Mus musculus ATP1B1/ATP4B .............marg..k ake..........egswkkf iwNsekkeflGRTggsWfkI llfYviFYgclagiFigtiq vmllTisel.kPtyqdr... va.pPGltqiPqiq.....k teisfrpn.dpksyeayvln iirFLekYkdsaqkd..dmi fedCgnvpsepkergdinhe rgerkvCrFkldwlgn.... ..Csglnd.dsyGyreGkPC iiiKlNRvlg......fkPk ppknesletyplmmkynpnv ..............lpvqCt gkrded....kdkvgnieyf gmgg...yygfplqYyPYyg kllqpkYlqPllAvqft..n ltvdteirveCkayge.nig yse.kdrfqGrfdvkieiks ...........
P07340 Rattus norvegicus ATP1B1 .............marg..k ake..........egswkkf iwNsekkeflGRTggsWfkI llfYviFYgclagiFigtiq vmllTisel.kPtyqdr... va.pPGltqiPqiq.....k teisfrpn.dpksyeayvln iirFLekYkdsaqkd..dmi fedCgsmpsepkergefnhe rgerkvCrFkldwlgn.... ..Csglnd.esyGykeGkPC iiiKlNRvlg......fkPk ppknesletypltmkynpnv ..............lpvqCt gkrded....kdkvgnieyf gmgg...fygfplqYyPYyg kllqpkYlqPllAvqft..n ltldteirieCkayge.nig yse.kdrfqGrfdvkievks ...........
P05026 Homo sapiens ATP1B1/ATP1B .............marg..k ake..........egswkkf iwNsekkeflGRTggsWfkI llfYviFYgclagiFigtiq vmllTisef.kPtyqdr... va.pPGltqiPqiq.....k teisfrpn.dpksyeayvln ivrFLekYkdsaqrd..dmi fedCgdvpsepkergdfnhe rgerkvCrFklewlgn.... ..Csglnd.etyGykeGkPC iiiKlNRvlg......fkPk ppknesletyp.vmkynpnv ..............lpvqCt gkrded....kdkvgnveyf glgn...spgfplqYyPYyg kllqpkYlqPllAvqft..n ltmdteirieCkayge.nig yse.kdrfqGrfdvkievks ...........
Q9TT37 Oryctolagus cuniculus Beta 1 .............marg..k ake..........egswkkf iwNsekkeflGRTggsWfkI llfYviFYgclagiFigtiq vmllTisef.kPtyqdr... va.pPGltqvPqiq.....k teiafrps.dpksyeeyvvn ivrFLekYkdsaqkd..dmv fedCgdvpsepkergefnne rgqrkvCrFklnwlgn.... ..Csgidd.etyGykdGkPC iiiKlNRvlg......fkPk ppkndslefsp.gtkynpnv ..............lpvqCt gkrded....kekvgsmeyf gmgd...yagfplqYyPYyg kllqpkYlqPllAvqft..n ltmdteirieCkayge.nig yse.kdrfqGrfdvkievks ...........
P08251 Gallus gallus Beta-1 .............marg..k andg.........dgnwkkf iwNsekkellGRTggsWfkI llfYviFYgclagiFigtiq vmllTvsef.ePkyqdr... va.pPGltqvPqvq.....k teisftvn.dpksydpyvkn legFLnkYsageqtd..niv fqdCgdiptdykergpynda qgqkkvCkFkrewlen.... ..Csglqd.ntfGykdGkPC ilvKlNRiig......fkPk apeneslpsdl.agkynpyl ..............ipvhCv akrded....adkigmveyy gmgg...ypgfalqYyPYyg rllqpqYlqPlvAvqft..n ltydvevrveCkeygq.niq ysd.kdrfqGrfdikfdiks s..........
P05029 Torpedo californica Beta .............mare..k stdd.........gggwkkf lwdsekkqvlGRTgtsWfkI fvfYliFYgclagiFigtiq vmllTisdf.ePkyqdr... va.pPGlshsPyav.....k teisfsvs.npnsyenhvng lkelLknYneskqdg..ntp fedCgvipadyitrgpiees qgqkrvCrFllqwlkn.... ..Csgidd.psyGyseGkPC iiaKlNRilg......fyPk ppkngtdlpealqanynqyv ..............lpihCq akkeed....kvrigtieyf gmgg...vggfplqYyPYyg krlqknYlqPlvgiqft..n lthnvelrveCkvfgd.nia yse.kdrslGrfevkievks ...........
P30715 Bufo marinus Beta-1 .............mard..k nken.........dgswkkf lwdpekkefmGRTgssWfkI llfYlvFYgclagiFigtiq vlllTlsiy.ePkyqdr... va.pPGltqvPrav.....k aeisftvg.npstyedyvts lsnFLnqYnsskqdn..lal fedCgdkpkgyidrgaispd hgtkrsCqFkrewlge.... ..Csglnd.ttfGfneGkPC livKlNRivg......fkPr p...tnvdvpaavanlteni ..............iplhCk gkrped....dnnlldiqyy gmgg...ypgfplnYyPYyg rllqpnYlqPliAvqft..n itldtevrieCrayge.nll lse.kdrfqGrfdikiemks s..........
Q91580 Xenopus laevis Beta-1 .............mard..k aket.........dggwrkf iwNadkkeflGRTggsWfkI llfYliFYgclagiFigtiq vlllTisef.ePkyqdr... va.pPGltqlPrav.....k teisfsps.dsnsyqeyvks mdnFLskYnnekq.g..snm fedCgtipgpyhergalnkd egmkksCvFrrewlqn.... ..Csglnd.psyGfadGkPC vivKlNRila......fkPv ppqnns.lppemtlnynpyv ..............ipihCq akkeed....iekikevkyy gmgg...fagfpltYyPYyg kllqpdYlqPliAvqft..n itfdaevrieCkayge.nid yhd.kdrfqGrfdvkfdiks s..........
P51165 Anguilla anguilla Beta ..............mpa..a tkds.........dggwkkf lwNsekkeflGRTggsWakI llfYviFYgclagiFigtiq alllTindf.kPvyqdr... va.pPGlshtPrse.....k semsfkvg.dpstyqkyvka mhdFLqaYndskqen..mmk yedCgdtpksyinrgeldnn qgikkaCiFrrswldk.... ..Csgled.ptfGfseGkPC livKlNRivn......frPr pp.tsndsipeeaqskvqpd v.............ipiyCt nkreed....aakvreikyy giq.....egfplqYyPYyg kqlhpqYlqPlvAvhft..n ltmatelrieCrvygq.nia ysd.kdryrGrfdvkftine s..........
Identical in 30 out of 40 sequences -------------M------ -------------------F --N-------GRT--SW--I -LFY--FY--L---F----- ----T------P-Y-D---- ----PGL---P--------- -------------------- ---FL--Y----Q------- ---C---------------- ------C-F----L------ --CSG--D----G---G-PC ---K-NR-----------P- -------------------- ------------------C- ------------------Y- ------------L-Y-PYYG K-----Y--PL-AV------ -----E---EC------N-- -----D---G----K----- -----------
Identical in 35 out of 40 sequences -------------------- -------------------- --N-------GRT---W--I ---Y--FY------F----- ----T------P-------- ----PG----P--------- -------------------- ---FL--Y------------ ---C---------------- ------C-F----------- --C---------G---G-PC ---K-NR-----------P- -------------------- ------------------C- -------------------- --------------Y-PY-- ------Y--P--A------- ----------C--------- ---------G---------- -----------
Identical in 37 out of 40 sequences -------------------- -------------------- ----------GRT---W--I ---Y--FY------F----- ----T------P-------- ----PG----P--------- -------------------- ----L--Y------------ ---C---------------- ------C------------- --C---------G-----PC ---K-N-------------- -------------------- ------------------C- -------------------- --------------Y-PY-- ------Y--P---------- ----------C--------- ---------G---------- -----------
Identical in all 40 sequences -------------------- -------------------- ----------GR----W--- ---Y---Y------------ -----------P-------- ----PG----P--------- -------------------- -------------------- -------------------- -------------------- ------------------P- -------------------- -------------------- ------------------C- -------------------- ----------------P--- -------------------- -------------------- -------------------- -----------
Transmembrane Helix 1 11111111111111111111 1111
Disulfide Bridges 1 1 2 2 3 3
Confirmed occurences of N-linked carbohydrates x x x x x x x x
(highlighted with magenta colouration, NB NOT conserved in all the proteins)
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